Brandling-Bennett A D, Oloo A J, Khan B, Watkins W M
Clinical Research Centre, Kenya Medical Research Institute, Nairobi.
Trans R Soc Trop Med Hyg. 1988;82(3):363-5. doi: 10.1016/0035-9203(88)90119-8.
58 children aged 1 to 10 years who had pure Plasmodium falciparum infections acquired on the coast of Kenya were treated with chloroquine 25 mg/kg given over 3 d and erythromycin 10 mg/kg 4 times a day given for 7 d. After 4 weeks follow-up, 62% had recurrent infections and 11% failed to clear their parasitaemia (1 had an RIII pattern of resistance). Of 38 children treated with chloroquine 25 mg/kg alone, 55% had recurrences and 21% failed to clear (including 1 RIII). In vitro microtests classified 74% of isolates from initial infections and 91% of isolates from recurrent infections as resistant. Erythromycin does not improve chloroquine treatment in children with infections due to P. falciparum having low to moderate levels of chloroquine resistance.
对58名年龄在1至10岁、在肯尼亚海岸感染单纯恶性疟原虫的儿童，给予氯喹25mg/kg，分3天服用，以及红霉素10mg/kg，每日4次，服用7天进行治疗。经过4周随访，62%的儿童出现复发性感染，11%未能清除其寄生虫血症（1例具有III级抗药模式）。在仅用25mg/kg氯喹治疗的38名儿童中，55%出现复发，21%未能清除（包括1例III级抗药）。体外微量试验将74%的初始感染分离株和91%的复发性感染分离株分类为抗药。对于感染氯喹耐药水平低至中等的恶性疟原虫的儿童，红霉素并不能改善氯喹治疗效果。
