Tharavanij S, Tapchaisri P, Mahakunkijcharoen Y, Looareesuwan S
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1988;82(3):385-8. doi: 10.1016/0035-9203(88)90128-9.
An indirect fluorescent antibody test for glutaraldehyde-fixed, ring-infected erythrocyte surface antigen was performed on admission sera from 45 patients with complicated cerebral Plasmodium falciparum malaria, 33 with uncomplicated cerebral malaria, 91 non-cerebral malaria patients, and 53 blood donors from a non-malarious area. 14 (31%), 28 (85%), 64 (70%), and 1 (2%), respectively, had titres greater than or equal to 1/25, considered as positive. The seropositive rate and the geometric mean reciprocal titre of patients with complicated cerebral malaria were significantly lower than those of uncomplicated and non-cerebral patients, particularly in the 6-14 and 15-29 year age groups. Compared with non-cerebral patients, lower seropositive rates for patients with complicated cerebral malaria were demonstrated only in those who had been ill 4 or more days before admission; whereas lower rates for patients with complications, when compared with rates in those with uncomplicated cerebral malaria, occurred irrespective of the duration of illness.
对45例伴有并发症的脑型恶性疟患者、33例无并发症的脑型疟患者、91例非脑型疟患者以及53名来自非疟疾流行区的献血者的入院血清，进行了针对戊二醛固定的、环状感染红细胞表面抗原的间接荧光抗体检测。结果分别有14例（31%）、28例（85%）、64例（70%）和1例（2%）的滴度大于或等于1/25，被视为阳性。伴有并发症的脑型疟患者的血清阳性率和几何平均倒数滴度显著低于无并发症和非脑型疟患者，尤其是在6至14岁和15至29岁年龄组。与非脑型疟患者相比，伴有并发症的脑型疟患者仅在入院前患病4天或更长时间的患者中血清阳性率较低；而与无并发症的脑型疟患者相比，并发症患者的血清阳性率较低，且与患病时长无关。
