NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
PLoS One. 2019 Jan 28;14(1):e0210823. doi: 10.1371/journal.pone.0210823. eCollection 2019.
A few days of bed rest or immobilization following injury, disease, or surgery can lead to considerable loss of skeletal muscle mass and strength. It has been speculated that such short, successive periods of muscle disuse may be largely responsible for the age-related loss of muscle mass throughout the lifespan.
To assess whether a single intramuscular injection of nandrolone decanoate prior to immobilization can attenuate the loss of muscle mass and strength in vivo in humans.
DESIGN, SETTING AND PARTICIPANTS: Thirty healthy (22 ± 1 years) men were subjected to 7 days of one-legged knee immobilization by means of a full leg cast with (NAD, n = 15) or without (CON, n = 15) prior intramuscular nandrolone decanoate injection (200 mg).
Before and immediately after immobilization, quadriceps muscle cross-sectional area (CSA) (by means of single-slice computed tomography (CT) scans of the upper leg) and one-legged knee extension strength (one-repetition maximum [1-RM]) were assessed for both legs. Furthermore, muscle biopsies from the immobilized leg were taken before and after immobilization to assess type I and type II muscle fiber cross-sectional area.
Quadriceps muscle CSA decreased during immobilization in both CON and NAD (-6 ± 1% and -6 ± 1%, respectively; main effect of time P<0.01), with no differences between the groups (time × treatment interaction, P = 0.59). Leg muscle strength declined following immobilization (-6 ± 2% in CON and -7 ± 3% in NAD; main effect of time, P<0.05), with no differences between groups (time × treatment interaction, P = 0.55).
This is the first study to report that nandrolone decanoate administration does not preserve skeletal muscle mass and strength during a short period of leg immobilization in vivo in humans.
受伤、患病或手术后卧床休息或固定几天，可能会导致大量骨骼肌质量和力量丧失。人们推测，这种短暂的、连续的肌肉失用可能在很大程度上导致了整个生命周期中与年龄相关的肌肉质量丧失。
评估在固定前单次肌肉内注射癸酸诺龙是否可以减轻人类体内肌肉质量和力量的丧失。
设计、设置和参与者：30 名健康男性（22 ± 1 岁），通过全腿石膏使单腿膝关节固定 7 天（NAD，n = 15）或不固定（CON，n = 15），同时接受肌肉内癸酸诺龙注射（200 mg）。
在固定前和固定后立即，通过对大腿的单次切片计算机断层扫描（CT）扫描评估股四头肌横截面积（CSA），并评估单腿膝关节伸展力量（1 次重复最大[1-RM]）。此外，在固定前后从固定腿中取出肌肉活检，以评估 I 型和 II 型肌纤维横截面积。
CON 和 NAD 组的股四头肌 CSA 在固定期间均下降（分别为-6 ± 1%和-6 ± 1%；时间的主要效应 P<0.01），两组之间无差异（时间×治疗相互作用，P = 0.59）。固定后腿部肌肉力量下降（CON 组为-6 ± 2%，NAD 组为-7 ± 3%；时间的主要效应，P<0.05），两组之间无差异（时间×治疗相互作用，P = 0.55）。
这是第一项研究报告，即在体内短期腿部固定期间，癸酸诺龙给药不能保留骨骼肌质量和力量。
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