Leiden University Medical Center, Department of Clinical Pharmacy & Toxicology, Leiden, The Netherlands.
Leiden University Medical Center, Department of Clinical Pharmacy & Toxicology, Leiden, The Netherlands.
Drug Discov Today. 2019 Mar;24(3):890-897. doi: 10.1016/j.drudis.2019.01.012. Epub 2019 Jan 25.
Adverse drug reactions (ADRs) that diminish sexual functioning can seriously affect a person's quality of life and can also affect drug adherence. However, no comprehensive overview on the subject is available and a lack of knowledge among healthcare professionals might be present. This systematic review of Summary of Products Characteristics identified 346 drugs registered with at least one sexual ADR. The drug class 'nervous system' (N) was represented most frequently with 105 drugs, followed by 'cardiovascular system' (C) with 89 drugs. For 16 drugs an incidence rate for sexual ADR of >10% was reported and for 98 drugs there was an incidence rate >1%. Because sexual ADRs occur in frequently used drugs, they should be considered in clinical practice to optimize drug treatment.
药物不良反应（ADR）会降低性功能，严重影响患者的生活质量，还可能影响药物的依从性。但是，目前尚无关于该主题的综合概述，医护人员对此可能了解不足。本系统综述对产品特性摘要进行了分析，确定了至少有一种与性功能障碍相关不良反应的 346 种药物。药物类别“神经系统”（N）的药物数量最多，有 105 种，其次是“心血管系统”（C），有 89 种。有 16 种药物报告的性功能障碍不良反应发生率超过 10%，98 种药物的发生率超过 1%。由于性功能障碍不良反应常见于常用药物中，因此在临床实践中应考虑这些不良反应，以优化药物治疗。
