School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.
School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia; School of Mechanical Engineering, Huaihai Institute of Technology, Lianyungang, Jiangsu 222005, China.
Acta Biomater. 2019 Mar 15;87:273-284. doi: 10.1016/j.actbio.2019.01.051. Epub 2019 Jan 26.
Titanium (Ti) based tissue engineering scaffolds can be used to repair damaged bone. However, successful orthopedic applications of these scaffolds rely on their ability to mimic the mechanical properties of trabecular bone. Selective laser melting (SLM) was used to manufacture scaffolds of a new β-Ti35Zr28Nb alloy for biomedical applications. Porosity values of the scaffolds were 83% for the FCCZ structure (face centered cubic unit cell with longitudinal struts) and 50% for the FBCCZ structure (face and body centered cubic unit cell with longitudinal struts). The scaffolds had an elastic modulus of ∼1 GPa and a plateau strength of 8-58 MPa, which fall within the values of trabecular bone (0.2-5 GPa for elastic modulus and 4-70 MPa for compressive strength). The SLM-manufactured β-Ti35Zr28Nb alloy showed good corrosion properties. MTS assay revealed that both the FCCZ and FBCCZ scaffolds had a cell viability similar to the control. SEM observation indicated that the osteoblast-like cells adhered, spread and grew healthily on the surface of both scaffolds after culture for 7, 14 and 28 d, demonstrating good biocompatibility. Overall, the SLM-manufactured Ti35Zr28Nb scaffolds possess promising potential as hard-tissue implant materials due to their appropriate mechanical properties, good corrosion behavior and biocompatibility. STATEMENT OF SIGNIFICANCE: Novel β Ti35Zr28Nb alloy scaffolds with FCCZ and FBCCZ structures were successfully fabricated by selective laser melting (SLM) for biomedical applications. The scaffolds showed values of elastic modulus of ∼1 GPa and plateau strength of 8-58 MPa, which fall within the ranges of the mechanical properties of trabecular bone. The SLM-manufactured β Ti35Zr28Nb alloy showed good corrosion properties. Both SLM-manufactured FCCZ and FBCCZ scaffolds exhibited good biocompatibility, with osteoblast-like cells attaching, growing, and spreading in a healthy way on their surfaces after culturing for different periods up to 28 d.
钛（Ti）基组织工程支架可用于修复受损骨骼。然而，这些支架在骨科中的成功应用依赖于其模仿小梁骨机械性能的能力。选择性激光熔化（SLM）被用于制造用于生物医学应用的新型β-Ti35Zr28Nb 合金支架。支架的 FCCZ 结构（具有纵向支柱的面心立方单元）的孔隙率为 83%，FBCCZ 结构（具有纵向支柱的面心立方和体心立方单元）的孔隙率为 50%。支架的弹性模量约为 1GPa，平台强度为 8-58MPa，处于小梁骨的范围内（弹性模量为 0.2-5GPa，压缩强度为 4-70MPa）。SLM 制造的β-Ti35Zr28Nb 合金表现出良好的耐腐蚀性。MTS 测定表明，FCCZ 和 FBCCZ 支架的细胞活力与对照相似。SEM 观察表明，成骨细胞样细胞在培养 7、14 和 28d 后在两种支架表面均附着、展开并健康生长，表现出良好的生物相容性。总体而言，由于其适当的机械性能、良好的耐腐蚀性和生物相容性，SLM 制造的 Ti35Zr28Nb 支架具有作为硬组织植入物材料的潜在应用前景。
