Chen Xionggang, Zhou Jianhong, Qian Yu, Zhao LingZhou
Institute of Physics & Optoelectronics Technology, Baoji Advanced Titanium Alloys and Functional Coatings Cooperative Innovation Center, Baoji University of Arts and Sciences, Baoji, 721016, PR China.
Department of Stomatology, Air Force Medical Center, The Fourth Military Medical University, Beijing, 100142, PR China.
Mater Today Bio. 2023 Feb 15;19:100586. doi: 10.1016/j.mtbio.2023.100586. eCollection 2023 Apr.
With the aging of population and the rapid improvement of public health and medical level in recent years, people have had an increasing demand for orthopedic implants. However, premature implant failure and postoperative complications frequently occur due to implant-related infections, which not only increase the social and economic burden, but also greatly affect the patient's quality of life, finally restraining the clinical use of orthopedic implants. Antibacterial coatings, as an effective strategy to solve the above problems, have been extensively studied and motivated the development of novel strategies to optimize the implant. In this paper, a variety of antibacterial coatings recently developed for orthopedic implants were briefly reviewed, with the focus on the synergistic multi-mechanism antibacterial coatings, multi-functional antibacterial coatings, and smart antibacterial coatings that are more potential for clinical use, thereby providing theoretical references for further fabrication of novel and high-performance coatings satisfying the complex clinical needs.
近年来，随着人口老龄化以及公共卫生和医疗水平的快速提高，人们对骨科植入物的需求日益增加。然而，由于与植入物相关的感染，植入物过早失效和术后并发症频繁发生，这不仅增加了社会和经济负担，还极大地影响了患者的生活质量，最终限制了骨科植入物的临床应用。抗菌涂层作为解决上述问题的有效策略，已得到广泛研究，并推动了优化植入物的新策略的发展。本文简要综述了近年来为骨科植入物开发的各种抗菌涂层，重点关注具有协同多机制的抗菌涂层、多功能抗菌涂层以及在临床应用中更具潜力的智能抗菌涂层，从而为进一步制备满足复杂临床需求的新型高性能涂层提供理论参考。
