Sims Jordyn A, Kapse Kushal, Glynn Peter, Sandberg Chaleece, Tripodis Yorghos, Kiran Swathi
Aphasia Research Laboratory, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Ave., Boston MA 02215, USA.
Aphasia Research Laboratory, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Ave., Boston MA 02215, USA.
Neuropsychologia. 2016 Apr;84:113-26. doi: 10.1016/j.neuropsychologia.2015.10.019. Epub 2016 Jan 13.
Recovery from aphasia, loss of language following a cerebrovascular incident (stroke), is a complex process involving both left and right hemispheric regions. In our study, we analyzed the relationships between semantic processing behavioral data, lesion size and location, and percent signal change from functional magnetic resonance imaging (fMRI) data. This study included 14 persons with aphasia in the chronic stage of recovery (six or more months post stroke), along with normal controls, who performed semantic processing tasks of determining whether a written semantic feature matched a picture or whether two written words were related. Using region of interest (ROI) analysis, we found that left inferior frontal gyrus pars opercularis and pars triangularis, despite significant damage, were the only regions to correlate with behavioral accuracy. Additionally, bilateral frontal regions including superior frontal gyrus, middle frontal gyrus, and anterior cingulate appear to serve as an assistive network in the case of damage to traditional language regions that include inferior frontal gyrus, middle temporal gyrus, supramarginal gyrus, and angular gyrus. Right hemisphere posterior regions including right middle temporal gyrus, right supramarginal gyrus, and right angular gyrus are engaged in the case of extensive damage to left hemisphere language regions. Additionally, right inferior frontal gyrus pars orbitalis is presumed to serve a monitoring function. These results reinforce the importance of the left hemisphere in language processing in aphasia, and provide a framework for the relative importance of left and right language regions in the brain.
失语症是脑血管事件（中风）后出现的语言丧失，从失语症中恢复是一个复杂的过程，涉及左右脑半球区域。在我们的研究中，我们分析了语义处理行为数据、病变大小和位置以及功能磁共振成像（fMRI）数据中的信号变化百分比之间的关系。本研究包括14名处于慢性恢复期（中风后六个月或更长时间）的失语症患者以及正常对照组，他们执行语义处理任务，即确定书面语义特征是否与图片匹配或两个书面单词是否相关。使用感兴趣区域（ROI）分析，我们发现左侧额下回 opercularis 部和三角部尽管受到严重损伤，但却是唯一与行为准确性相关的区域。此外，在包括额下回、颞中回、缘上回和角回在内的传统语言区域受损的情况下，双侧额叶区域，包括额上回、额中回和前扣带回，似乎起到辅助网络的作用。在左侧半球语言区域广泛受损的情况下，右侧半球后部区域，包括右侧颞中回、右侧缘上回和右侧角回会被激活。此外，右侧额下回眶部被认为起到监测功能。这些结果强化了左半球在失语症语言处理中的重要性，并为大脑中左右语言区域的相对重要性提供了一个框架。
