Ahmad Fahim, Sun Qian, Patel Deven, Stommel Jayne M
National Institutes of Health, National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892, USA.
Cancers (Basel). 2019 Jan 26;11(2):146. doi: 10.3390/cancers11020146.
Glioblastoma is a highly lethal adult brain tumor with no effective treatments. In this review, we discuss the potential to target cholesterol metabolism as a new strategy for treating glioblastomas. Twenty percent of cholesterol in the body is in the brain, yet the brain is unique among organs in that it has no access to dietary cholesterol and must synthesize it de novo. This suggests that therapies targeting cholesterol synthesis in brain tumors might render their effects without compromising cell viability in other organs. We will describe cholesterol synthesis and homeostatic feedback pathways in normal brain and brain tumors, as well as various strategies for targeting these pathways for therapeutic intervention.
胶质母细胞瘤是一种极具致死性的成人脑肿瘤，目前尚无有效的治疗方法。在本综述中，我们讨论了将胆固醇代谢作为治疗胶质母细胞瘤的新策略的潜力。人体中20%的胆固醇存在于大脑中，但大脑在器官中独具特色，因为它无法获取膳食胆固醇，必须从头合成胆固醇。这表明，针对脑肿瘤中胆固醇合成的疗法可能在不损害其他器官细胞活力的情况下发挥作用。我们将描述正常大脑和脑肿瘤中的胆固醇合成及稳态反馈途径，以及针对这些途径进行治疗干预的各种策略。
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