Kloft H M, Ramsay E C, Sula M M
Department of Biomedical and Diagnostic Services, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee, USA.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee, USA.
J Comp Pathol. 2019 Jan;166:35-44. doi: 10.1016/j.jcpa.2018.10.178. Epub 2018 Nov 30.
This retrospective study identified the spectrum of neoplasia diagnoses, prevalence rates and the contribution of neoplasia to death or humane destruction within Panthera species housed at a large cat sanctuary. Biopsy and necropsy reports from January 2002 to December 2017 were examined and histological material from cases diagnosed with neoplasia was reviewed. One hundred and sixty-eight neoplasms were diagnosed in 108 large felids: 70 tigers (Panthera tigris), 26 lions (Panthera leo), three ligers (P. leo × P. tigris), eight leopards (Panthera pardus) and one jaguar (Panthera onca). Forty-four felids had multiple neoplasms. The overall neoplasia rate (animals with neoplasms/all Panthera spp. pathology accessions) was 50.2%. Neoplasms predominantly originated from the reproductive (n = 47), endocrine (n = 27) and integumentary (n = 24) systems, with mammary carcinoma the most common neoplasm (n = 28). Mammary carcinomas comprised 59.6% of the reproductive tumours diagnosed and commonly metastasized widely. Neoplasia was the cause of death or humane destruction in 50.9% of the animals diagnosed with neoplasms. All lymphomas (n = 16) were responsible for death or humane destruction. This study shows that malignant and benign neoplasms are present in approximately half of ageing, captive Panthera spp., and that half of these animals will die or be humanely destroyed as a result of their neoplasms.
这项回顾性研究确定了大型猫科动物保护区内圈养的豹属动物的肿瘤诊断范围、患病率以及肿瘤对死亡或安乐死的影响。研究人员查阅了2002年1月至2017年12月期间的活检和尸检报告，并对诊断为肿瘤的病例的组织学材料进行了复查。在108只大型猫科动物中诊断出168例肿瘤：70只老虎（ Panthera tigris）、26只狮子（ Panthera leo）、3只狮虎兽（ P. leo × P. tigris）、8只豹（ Panthera pardus）和1只美洲豹（ Panthera onca）。44只猫科动物患有多种肿瘤。总体肿瘤发生率（患有肿瘤的动物数/所有豹属动物病理检查病例数）为50.2%。肿瘤主要起源于生殖系统（n = 47）、内分泌系统（n = 27）和皮肤系统（n = 24），其中乳腺癌是最常见的肿瘤（n = 28）。乳腺癌占诊断出的生殖系统肿瘤的59.6%，并且通常广泛转移。在诊断出患有肿瘤的动物中，50.9%的动物的死亡或安乐死是由肿瘤引起的。所有淋巴瘤（n = 16）都导致了死亡或安乐死。这项研究表明，在大约一半的老龄圈养豹属动物中存在恶性和良性肿瘤，并且这些动物中有一半将因肿瘤而死亡或被安乐死。
