Moresco Anneke, Muñoz Karina E, Gutiérrez Federico, Arias-Bernal Leonardo, Yarto-Jaramillo Enrique, Teixeira Rodrigo H F, Peña-Stadlin Juliana, Troan Brigid V
Animal Welfare and Research, Denver Zoo, Denver, CO 80205, USA.
Exotic Species Cancer Research Alliance, North Carolina State University, Raleigh, NC 27607, USA.
Animals (Basel). 2020 Dec 11;10(12):2376. doi: 10.3390/ani10122376.
As evidenced by numerous case reports from zoos, neoplasia in felids is common, but most reports are limited to species in North America or Europe. In order to obtain a wider epidemiologic understanding of neoplasia distribution, necropsy records at seven facilities (USA, Mexico, Colombia, Peru, and Brazil) were evaluated. In contrast to others, this study population (195 cases, 16 species), included many non- felids. Overall neoplasia prevalence was 28.2% (55/195). species had a higher prevalence of neoplasia than non- species (52.5%; vs. 13.0%). Lions (66.7%), jaguars (55.0%), and tigers (31.3%) had the highest species-specific prevalence of neoplasia. Neoplasms in species were more frequently malignant than in non- (86.1% vs. 55.6%). The systems most commonly affected were the reproductive, hematolymphoid, and respiratory. The range of management conditions and more varied genetic backgrounds support a robust taxonomic pattern and suggest that the reported propensity for neoplasia in jaguars may have a genetic basis at a taxonomic level higher than species, as lions and tigers also have high prevalence. Given the high prevalence of neoplasia and high likelihood of malignancy, routine medical exams in all nondomestic felids, but species in particular, should include thorough assessments of any clinical signs of neoplasia.
动物园的大量病例报告表明，猫科动物的肿瘤形成很常见，但大多数报告仅限于北美或欧洲的物种。为了更广泛地了解肿瘤形成的分布情况，对七个机构（美国、墨西哥、哥伦比亚、秘鲁和巴西）的尸检记录进行了评估。与其他研究不同，本研究群体（195例，16个物种）包括许多非猫科动物。总体肿瘤形成患病率为28.2%（55/195）。某些物种的肿瘤形成患病率高于非某些物种（52.5%；相比之下为13.0%）。狮子（66.7%）、美洲虎（55.0%）和老虎（31.3%）的特定物种肿瘤形成患病率最高。某些物种的肿瘤比非某些物种的肿瘤更常为恶性（86.1%对55.6%）。最常受影响的系统是生殖系统、血液淋巴系统和呼吸系统。管理条件的范围和更多样化的遗传背景支持了一种强大的分类模式，并表明美洲虎中报告的肿瘤形成倾向可能在高于物种的分类水平上有遗传基础，因为狮子和老虎的患病率也很高。鉴于肿瘤形成的高患病率和恶性的高可能性，所有非家养猫科动物，特别是某些物种的常规医学检查，应包括对任何肿瘤临床症状的全面评估。
