辅助受孕并不会增加乙型肝炎病毒母婴传播的风险，与自然受孕相比：一项前瞻性队列研究。
Assisted conception does not increase the risk for mother-to-child transmission of hepatitis B virus, compared with natural conception: a prospective cohort study.
机构信息
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, People's Republic of China.
出版信息
Fertil Steril. 2019 Feb;111(2):348-356. doi: 10.1016/j.fertnstert.2018.10.021.
OBJECTIVE
To determine whether assisted conception increases the risk for mother-to-child transmission of hepatitis B virus (HBV) infection compared with natural conception.
DESIGN
Prospective cohort study.
SETTING
Research laboratory.
PATIENT(S): A total of 305 children, 176 born with assisted conception and 129 born with natural conception, were born to a total of 251 hepatitis B surface antigen- (HBsAg-) positive women.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): The seropositive rates of HBsAg in children at birth and HBV infection rates at 9-15 months of age.
RESULT(S): Overall, 7.5% (23/305) of children were HBsAg-positive at birth. The rate of HBsAg-positive children at birth did not significantly differ between children in the assisted conception group compared with those in the natural conception group (6.3% [11/176] vs. 9.3% [12/129]). Multivariate logistic regression analysis showed that conception method is not related to the rate of HBsAg-positive children at birth. All children who were positive for HBsAg at birth and were followed up for 9-15 months became negative for HBsAg after hepatitis B immunization.
CONCLUSION(S): Assisted conception does not increase the risk for mother-to-child transmission of HBV compared with natural conception.
目的
与自然受孕相比，确定辅助受孕是否会增加乙型肝炎病毒（HBV）母婴传播的风险。
设计
前瞻性队列研究。
地点
研究实验室。
患者
共有 305 名儿童，其中 176 名是通过辅助受孕出生的，129 名是通过自然受孕出生的，他们共有 251 名乙型肝炎表面抗原（HBsAg）阳性的母亲。
干预措施
无。
主要观察指标
儿童出生时 HBsAg 的血清阳性率和 9-15 个月时 HBV 感染率。
结果
总的来说，7.5%（23/305）的儿童在出生时 HBsAg 阳性。与自然受孕组相比，辅助受孕组 HBsAg 阳性儿童的比例并无显著差异（6.3%[11/176]vs.9.3%[12/129]）。多变量逻辑回归分析显示，受孕方式与 HBsAg 阳性儿童的出生比例无关。所有在出生时 HBsAg 阳性并在 9-15 个月时进行随访的儿童在乙型肝炎免疫接种后 HBsAg 转为阴性。
结论
与自然受孕相比，辅助受孕并未增加 HBV 的母婴传播风险。
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