缺氧诱导因子促进乳腺癌干细胞在缺氧或细胞毒性化疗时的特化和维持。
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy.
机构信息
Department of Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
Institute for Cell Engineering, McKusick-Nathans Institute of Genetic Medicine, and Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
出版信息
Adv Cancer Res. 2019;141:175-212. doi: 10.1016/bs.acr.2018.11.001. Epub 2018 Dec 19.
Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.
临床研究表明，乳腺癌中存在肿瘤内缺氧区域（氧气供应减少），这会激活缺氧诱导因子（HIFs）。肿瘤内缺氧与远处转移和癌症死亡率之间的关系已得到充分证实。肿瘤内缺氧促进疾病进展的一个主要机制是诱导乳腺癌干细胞（BCSC）表型。BCSCs 是一小部分具有自我更新能力的细胞亚群。BCSCs 与化疗耐药性、疾病复发和转移有关。在这篇综述中，我们将讨论我们目前对 HIF 依赖性诱导 BCSC 表型的分子机制的理解，以应对缺氧或化疗。
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