Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, CWRU School of Medicine, 9500 Euclid Avenue/A90, Cleveland, OH 4419, USA.
Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, CWRU School of Medicine, 9500 Euclid Avenue/A90, Cleveland, OH 4419, USA.
Clin Chest Med. 2019 Mar;40(1):107-123. doi: 10.1016/j.ccm.2018.10.017. Epub 2018 Dec 20.
This article on exposome and asthma focuses on the interaction of patients and their environments in various parts of their growth, development, and stages of life. Indoor and outdoor environments play a role in pathogenesis via levels and duration of exposure, with genetic susceptibility as a crucial factor that alters the initiation and trajectory of common conditions such as asthma. Knowledge of environmental exposures globally and changes that are occurring is necessary to function effectively as medical professionals and health advocates.
这篇关于暴露组学和哮喘的文章重点关注患者及其所处环境在其生长、发育和生命阶段的各个方面的相互作用。室内和室外环境通过暴露水平和持续时间在发病机制中发挥作用，遗传易感性是改变哮喘等常见疾病的起始和轨迹的关键因素。了解全球环境暴露情况及其变化对于医疗专业人员和健康倡导者有效发挥作用是必要的。
