Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Severe Asthma Unit, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Int J Mol Sci. 2023 Jun 21;24(13):10467. doi: 10.3390/ijms241310467.
Climate change and exposure to environmental pollutants play a key role in the onset and aggravation of allergic diseases. As different climate-dependent patterns of molecular immunoglobulin E (IgE) reactivity have been regionally described, we sought to investigate the evolving allergen exposome in distinctive allergic phenotypes and subtropical weather conditions through a Precision Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several house dust mites (HDM) and storage mite molecules were broadly dominant in the investigated cohort, followed by the major cat allergen Fel d 1, and regardless of the basal allergic disease. Although a complex repertoire of allergens was recognized, a steadily increasing number of IgE binding molecules was associated with the complexity of the underlying atopic disease. Besides the highly prevalent IgE responses to major HDM allergens, Der p 21, Der p 5, and Der p 7 also showed up as serodominant molecules, especially in subjects bothered by asthma and atopic dermatitis. The accurate characterization of the external exposome at the molecular level and their putative role as clinically relevant allergens is essential to elucidate the phenotypic diversity of atopic disease in terms of personalized diagnosis and therapy.
气候变化和环境污染物暴露在过敏性疾病的发生和恶化中起着关键作用。由于不同的气候依赖性分子免疫球蛋白 E（IgE）反应模式已在区域上进行了描述，我们通过 Precision Allergy Molecular Diagnosis（PAMD@）模型，旨在探究在独特的过敏表型和亚热带天气条件下，不断演变的过敏原暴露组。在研究队列中，同时对几种屋尘螨（HDM）和贮藏螨分子产生过敏反应广泛占主导地位，其次是主要的猫过敏原 Fel d 1，且与基础过敏疾病无关。尽管识别出了复杂的过敏原谱，但与潜在特应性疾病的复杂性相关的 IgE 结合分子数量不断增加。除了对主要 HDM 过敏原的高度流行 IgE 反应外，Der p 21、Der p 5 和 Der p 7 也表现为血清优势分子，尤其是在受哮喘和特应性皮炎困扰的患者中。在分子水平上准确描述外部暴露组及其作为临床相关过敏原的潜在作用，对于阐明特应性疾病的表型多样性，从个性化诊断和治疗的角度来看至关重要。
