School of Economics and Management, Center for Innovation Management Research, Xinjiang University, Xinjiang 830047, PR China.
Collaborative Innovation Center for Advanced Nuclear Energy Technology, INET, Tsinghua University, Beijing 100084, PR China.
Waste Manag. 2019 Feb 1;84:141-146. doi: 10.1016/j.wasman.2018.11.039. Epub 2018 Nov 27.
Antibiotic fermentation residues are a kind of hazardous waste due to the existence of the residual antibiotics and the potential risk to generate antibiotics resistance genes (ARGs). The appropriate treatment and disposal of antibiotic fermentation residues is imperative. In this study ionizing radiation was applied to treat the antibiotic fermentation residues and the removal efficiencies of antibiotic (erythromycin), ARGs (ermB and ermF) and antibiotic resistant bacteria were investigated. The experimental results showed that erythromycin A content in antibiotic fermentation residues decreased by 86% when the dose was 10 kGy. Moreover, the abundance of ermB and ermF reduced by 89% and 98% at 10 kGy irradiation. Over 99% of total bacteria was removed and antibiotic resistant bacteria (ARB) were less than detection limit after 10 kGy irradiation. Ionizing radiation process is a promising technology for simultaneously removing antibiotic and inactivating ARGs and ARB in antibiotic fermentation residues. Moreover, the irradiation at 10 kGy had no significant influence on the macromolecules organic matters (protein, polysaccharides) of the antibiotic fermentation residues, suggesting that the treated fermentative residues can be used as fertilizer, which could provide the technical support for the development of recycling economy in antibiotic pharmaceutical factory.
抗生素发酵残余物是一种危险废物，因为存在残留抗生素和产生抗生素耐药基因 (ARGs) 的潜在风险。因此，必须对抗生素发酵残余物进行适当的处理和处置。在本研究中，采用电离辐射处理抗生素发酵残余物，并考察了抗生素（红霉素）、ARGs（ermB 和 ermF）和抗生素抗性菌的去除效率。实验结果表明，当辐照剂量为 10 kGy 时，抗生素发酵残余物中红霉素 A 的含量下降了 86%。此外，在 10 kGy 辐照下，ermB 和 ermF 的丰度分别降低了 89%和 98%。经过 10 kGy 辐照后，总细菌去除率超过 99%，抗生素抗性菌（ARB）低于检测限。电离辐射技术是一种很有前途的技术，可同时去除抗生素和灭活抗生素发酵残余物中的 ARGs 和 ARB。此外，10 kGy 的辐照对抗生素发酵残余物中的大分子有机物（蛋白质、多糖）没有显著影响，表明处理后的发酵残余物可用作肥料，为抗生素制药厂发展循环经济提供技术支持。
