Umemura Kotaro, Miura Takuya, Ishido Keinosuke, Sakamoto Yoshiyuki, Kudo Daisuke, Kimura Norihisa, Morohashi Hajime, Hakamada Kenichi
Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2018 Dec;45(13):2199-2201.
A 35-year-old man was diagnosed with initially unresectable synchronous liver metastases from sigmoid colon cancer. We started FOLFOX plus panitumumab therapy. After 3courses of chemotherapy, the liver metastases became resectable. Sigmoidectomy, extended left lobectomy, and partial hepatectomy were performed. On the final histopathological analysis, all hepatic lesions were fibrotic without viable cancer cells. Nineteen months after the surgery, CT revealed isolated residual liver recurrence in segment 5. After partial hepatectomy, the patient is alive without recurrence. We report a case of pathological complete response with FOLFOX plus panitumumab therapy for initially unresectable colorectal liver metastases with icterus.
一名35岁男性被诊断为患有来自乙状结肠癌的初始不可切除的同步肝转移瘤。我们开始了FOLFOX联合帕尼单抗治疗。经过3个疗程的化疗后，肝转移瘤变得可切除。遂进行了乙状结肠切除术、扩大左叶切除术和部分肝切除术。在最后的组织病理学分析中，所有肝病变均为纤维化，无存活癌细胞。手术后19个月，CT显示5段出现孤立性残留肝复发。在进行部分肝切除术后，患者存活且无复发。我们报告了一例采用FOLFOX联合帕尼单抗治疗伴有黄疸的初始不可切除的结直肠癌肝转移而获得病理完全缓解的病例。
