[1例Ⅲ期食管胃交界腺癌对含SOX的术前化疗显示病理完全缓解]
[A Case of cStage Ⅲ Esophagogastric Junction Adenocarcinoma That Showed pCR to Preoperative Chemotherapy Containing SOX].
作者信息
Kobayashi Toshiyuki, Kosuga Toshiyuki, Kubota Takeshi, Okamoto Kazuma, Shoda Katsutoshi, Konishi Hirotaka, Shiozaki Atsushi, Fujiwara Hitoshi, Arita Tomohiro, Morimura Ryo, Murayama Yasutoshi, Kuriu Yoshiaki, Ikoma Hisashi, Nakanishi Masayoshi, Otsuji Eigo
机构信息
Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.
出版信息
Gan To Kagaku Ryoho. 2018 Dec;45(13):2369-2371.
A 68-year-old man was diagnosed with esophagogastric junction adenocarcinoma, cT4a(SE)N3aM0, cStage Ⅲ. Because "bulky N" was present, he was administered 2 courses of preoperative chemotherapy containing S-1 plus oxaliplatin(SOX). Both the primary tumor and enlarged lymph nodes had greatly decreased in size following chemotherapy, and total gastrectomy and lower esophagectomy with D2 lymphadenectomy were then performed. Histopathological examinations showed no residual cancer cell both in the primary lesion and dissected lymph nodes; thus, the efficacy of the chemotherapy was Grade 3. Preoperative chemotherapy containing SOX could be one of the useful treatment options for gastric cancer patients with extensive lymph node metastases including "bulky N".
一名68岁男性被诊断为食管胃交界腺癌，cT4a(SE)N3aM0，cⅢ期。由于存在“巨大淋巴结”，他接受了2个疗程含S-1加奥沙利铂（SOX）的术前化疗。化疗后，原发肿瘤和肿大淋巴结的大小均显著减小，随后进行了全胃切除术和食管下段切除术及D2淋巴结清扫术。组织病理学检查显示，原发灶和清扫淋巴结中均无残留癌细胞；因此，化疗疗效为3级。含SOX的术前化疗可能是伴有广泛淋巴结转移（包括“巨大淋巴结”）的胃癌患者的有效治疗选择之一。
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