自噬与心脏衰老。
Autophagy and cardiac aging.
机构信息
Department of Pharmacology, University of California, San Diego, 9500 Gilman drive, La Jolla, CA, 92093-0636, USA.
出版信息
Cell Death Differ. 2019 Mar;26(4):653-664. doi: 10.1038/s41418-019-0286-9. Epub 2019 Jan 28.
Abstract
Cardiovascular disease (CVD) is the leading cause of death and the prevalence of CVD dramatically increases with age. Cardiac aging is associated with hypertrophy, fibrosis, inflammation, and decreased contractility. Autophagy, a bulk degradation/recycling system, is essential to maintain cellular homeostasis. Cardiac autophagy is decreased with age, and misfolded proteins and dysfunctional mitochondria are accumulated in the aging heart. Inhibition of autophagy leads to exacerbated cardiac aging, while stimulation of autophagy improves cardiac function and also increases lifespan in many organisms. Thus autophagy represents a potential therapeutic target for aging-related cardiac dysfunction. This review discusses recent progress in our understanding of the role and regulation of autophagy in the aging heart.
摘要
心血管疾病（CVD）是主要的死亡原因，CVD 的患病率随着年龄的增长而显著增加。心脏衰老与肥大、纤维化、炎症和收缩力下降有关。自噬是一种大规模的降解/回收系统，对维持细胞内稳态至关重要。随着年龄的增长，心脏自噬减少，衰老心脏中堆积了错误折叠的蛋白质和功能失调的线粒体。自噬的抑制会导致心脏衰老加剧，而自噬的刺激则会改善心脏功能，并在许多生物中延长寿命。因此，自噬代表了与衰老相关的心脏功能障碍的一个潜在治疗靶点。本综述讨论了我们对自噬在衰老心脏中的作用和调节的最新认识。
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