Zhuang Hong, Zhang Xiaoliang, Wu Sijia, Yong Pang, Yan Haiyang
College of Food Science and Engineering, Jilin University, Changchun, 130062 Jilin China.
Food Sci Biotechnol. 2024 Sep 7;33(15):3445-3461. doi: 10.1007/s10068-024-01686-x. eCollection 2024 Dec.
With the increasing proportion of the global aging population, aging mechanisms and anti-aging strategies become hot topics. Nonetheless, the safety of non-natural anti-aging active molecule and the changes in physiological function that occur during aging have not been clarified. There is therefore a need to develop safer pharmaceutical interventions for anti-aging. Numerous types of research have shown that food-derived biomolecules are of great interest due to their unique contribution to anti-aging safety issues and the prevention of degenerative diseases. Among these, polyphenolic organic compounds are widely used in anti-aging research for their ability to mitigate the physiological functional changes that occur during aging. The mechanisms include the free radical theory, immune aging theory, cellular autophagy theory, epigenetic modification theory, gut microbial effects on aging theory, telomere shortening theory, etc. This review elucidates the mechanisms underlying the anti-aging effects of polyphenols found in food-derived bioactive molecules, while also addressing the challenges associated with anti-aging pharmaceuticals. The review concludes by offering insights into the current landscape of anti-aging active molecule research, aiming to serve as a valuable resource for further scholarly inquiry.
随着全球老龄化人口比例的不断增加，衰老机制和抗衰老策略成为热门话题。然而，非天然抗衰老活性分子的安全性以及衰老过程中发生的生理功能变化尚未明确。因此，需要开发更安全的抗衰老药物干预措施。大量研究表明，食物来源的生物分子因其在抗衰老安全性问题和预防退行性疾病方面的独特贡献而备受关注。其中，多酚类有机化合物因其能够减轻衰老过程中发生的生理功能变化而被广泛应用于抗衰老研究。其机制包括自由基理论、免疫衰老理论、细胞自噬理论、表观遗传修饰理论、肠道微生物对衰老的影响理论、端粒缩短理论等。本综述阐明了食物来源的生物活性分子中多酚类物质抗衰老作用的潜在机制，同时也探讨了抗衰老药物面临的挑战。综述最后对抗衰老活性分子研究的现状进行了深入分析，旨在为进一步的学术研究提供有价值的参考。
