Santangelo Gloria, Ielasi Alfonso, Pattarino Francesco, Saino Antonio Tommaso, Scopelliti Pasquale Antonio, Tespili Maurizio
Cardiology Division, Azienda Socio Sanitaria Territoriale Bergamo Est, Bolognini Hospital, Seriate (BG), Italy.
Interventional Cardiology Unit, S. Ambrogio Cardio-Thoracic Center, Milan, Italy.
J Cardiol Cases. 2018 Sep 27;19(1):19-21. doi: 10.1016/j.jccase.2018.08.007. eCollection 2019 Jan.
A 61-year-old man, admitted to our hospital for bilateral pulmonary embolism, complicated by right renal ischemia and multiple splenic infarcts due to a mobile thrombus entrapped in a patent foramen ovale, has been successfully treated with apixaban 5 mg twice daily followed by transcatheter patent foramen ovale closure. < Apixaban could be a therapeutic alternative to thrombolysis and surgery in patients with warfarin-resistant thrombus straddling in the patent foramen ovale (PFO). Furthermore, apixaban could be a simple and useful option to manage patients undergoing transcatheter PFO closure. Finally, in the evaluation and treatment of PFO, it is necessary to remember that it is associated not only with cryptogenic stroke but also with non-cerebral, paradoxical systemic embolic events such as myocardial infarction renal, infarct, and limb ischemia.>.
一名61岁男性因双侧肺栓塞入住我院，因卵圆孔未闭内的移动血栓并发右肾缺血和多发脾梗死，接受每日两次5毫克阿哌沙班治疗，随后行经导管卵圆孔未闭封堵术，治疗成功。<对于卵圆孔未闭（PFO）中存在对华法林耐药的跨隔血栓的患者，阿哌沙班可能是溶栓和手术的一种治疗替代方案。此外，阿哌沙班可能是管理行经导管PFO封堵术患者的一种简单且有用的选择。最后，在PFO的评估和治疗中，有必要记住它不仅与不明原因的卒中有关，还与非脑性、反常性全身栓塞事件有关，如心肌梗死、肾梗死和肢体缺血。>
