Khafaei Mostafa, Rezaie Ehsan, Mohammadi Ali, Shahnazi Gerdehsang Payam, Ghavidel Sara, Kadkhoda Sepideh, Zorrieh Zahra Atieh, Forouzanfar Narjes, Arabameri Hossein, Tavallaie Mahmood
Human Genetics Research Center, Baqiyatallah Medical Science University, Tehran, Iran.
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Science, Tehran, Iran.
J Cell Physiol. 2019 Sep;234(9):14651-14665. doi: 10.1002/jcp.28210. Epub 2019 Jan 28.
Malignant neoplasms are regarded as the main cause of death around the world; hence, many research studies were conducted to further perceive molecular mechanisms, treatment, and cancer prognosis. Cancer is known as a major factor for health-related problems in the world. The main challenges associated with these diseases are prompt diagnosis, disease remission classification and treatment status forecast. Therefore, progressing in such areas by developing new and optimized methods with the help of minimally invasive biological markers such as circular microRNAs (miRNAs) can be considered important. miRNA interactions with target genes have specified their role in development, apoptosis, differentiation, and proliferation and also, confirm direct miRNA function in cancer. Different miRNAs expression levels in various types of malignant neoplasms have been observed to be associated with prognosis of various carcinomas. miR-9 seems to implement opposite practices in different tissues or under various cancer incidences by influencing different genes. Aberrant miR-9 levels have been observed in many cancer types. Therefore, we intended to investigate the precise role of miR-9 in patients with malignant neoplasms. To this end, in this study, we attempted to examine different studies to clarify the overall role of miR-9 as a prognostic marker in several human tumors. The presented data in this study can help us to find the novel therapeutic avenues for treatment of human cancers.
恶性肿瘤被认为是全球主要的死亡原因；因此，人们开展了许多研究以进一步了解其分子机制、治疗方法和癌症预后。癌症是全球与健康相关问题的主要因素。与这些疾病相关的主要挑战是快速诊断、疾病缓解分类和治疗状态预测。因此，借助环状微小RNA（miRNA）等微创生物标志物开发新的优化方法，在这些领域取得进展可被视为至关重要。miRNA与靶基因的相互作用已明确其在发育、凋亡、分化和增殖中的作用，也证实了miRNA在癌症中的直接功能。在各种类型的恶性肿瘤中，不同miRNA的表达水平已被观察到与各种癌症的预后相关。miR-9似乎通过影响不同基因，在不同组织或不同癌症发生情况下发挥相反的作用。在许多癌症类型中都观察到miR-9水平异常。因此，我们旨在研究miR-9在恶性肿瘤患者中的精确作用。为此，在本研究中，我们试图审视不同的研究，以阐明miR-9作为几种人类肿瘤预后标志物的整体作用。本研究中呈现的数据可帮助我们找到治疗人类癌症的新治疗途径。
