State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming 650201 , People's Republic of China.
University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
Org Lett. 2019 Feb 15;21(4):1007-1010. doi: 10.1021/acs.orglett.8b04022. Epub 2019 Jan 29.
Phytochemical study of Hypericum ascyron led to the characterization of norascyronones A-C (1-3), metabolites derived from bicyclic polyprenylated acylphloroglucinols by losing eight carbons (C-2/3/4 of core and the isoprenyl at C-3). Compounds 1/2 with an unprecedented 6/6/5/6 ring system should be generated via [4 + 2] intramolecular cyclization of 3. Their structures were determined by spectroscopic and X-ray diffraction data. Compounds 1 and 2 showed cytotoxicities against the SK-BR-3 cell line (IC 4.3 and 7.8 μM).
贯叶金丝桃化学成分研究导致了 norascyronones A-C（1-3）的特征化，这些代谢物是通过失去八个碳原子（核心的 C-2/3/4 和 C-3 上的异戊烯基）从双环聚异戊烯基酰基间苯三酚衍生而来的。化合物 1/2 具有前所未有的 6/6/5/6 环系统，应该是通过 3 的[4+2]分子内环化生成的。它们的结构通过光谱和 X 射线衍射数据确定。化合物 1 和 2 对 SK-BR-3 细胞系表现出细胞毒性（IC 4.3 和 7.8 μM）。
