Gottlieb P A, Rossini A A, Mordes J P
Department of Medicine, University of Massachusetts Medical School, Worcester.
Diabetes Care. 1988 Nov-Dec;11 Suppl 1:29-36.
Animal models of insulin-dependent diabetes mellitus (IDDM) provide a uniquely valuable tool for understanding the pathogenesis of this disease. To the extent that they represent the human disease, they permit innovative approaches to its study. Four animal models--the BB rat, the nonobese diabetic mouse, the streptozocin-induced diabetic mouse, and the encephalomyocarditis virus-infected mouse--are reviewed. The salient characteristics of each model and the various techniques and immunotherapeutic agents used in conjunction with them to study prevention and reversal of IDDM are described, particularly the modulatory techniques directed at the cellular cytotoxic system, the regulatory immune system, and the beta-cell.
胰岛素依赖型糖尿病（IDDM）动物模型为理解该疾病的发病机制提供了一种独特且有价值的工具。就其代表人类疾病的程度而言，它们允许采用创新方法来进行研究。本文综述了四种动物模型——BB大鼠、非肥胖糖尿病小鼠、链脲佐菌素诱导的糖尿病小鼠以及脑心肌炎病毒感染小鼠。描述了每种模型的显著特征以及与之结合用于研究IDDM预防和逆转的各种技术和免疫治疗药物，特别是针对细胞毒性系统、调节性免疫系统和β细胞的调节技术。
