Hamburger J
C R Acad Sci III. 1986;303(8):299-301.
In type I (insulin-dependent) diabetes evidence for an autoimmune process is now fully established. This is also true for a similar disease observed in the NOD mouse and the BB rat. In addition to circulating antipancreatic antibodies, we demonstrated T-lymphocyte mediated cellular immunity in both these diabetic animals and in the human. Immunological abnormalities precede the development of diabetes and may be responsible for beta cell alteration. Evidence for this interpretation appears stronger for cell-mediated than for humoral immunity. However, full demonstration and understanding of the relationship between anti-beta cell immunity and beta cell alteration still raise many unresolved problems.
在I型（胰岛素依赖型）糖尿病中，自身免疫过程的证据现已完全确立。在非肥胖糖尿病（NOD）小鼠和BB大鼠中观察到的类似疾病也是如此。除了循环抗胰腺抗体外，我们在这些糖尿病动物和人类中都证明了T淋巴细胞介导的细胞免疫。免疫异常先于糖尿病的发生，可能是β细胞改变的原因。这种解释的证据在细胞介导免疫方面似乎比体液免疫更强。然而，对抗β细胞免疫与β细胞改变之间关系的充分证明和理解仍然存在许多未解决的问题。
