Cutuli Hernán J, Barciocco Carolina, Rojas Bilbao Érica, Brzezinski Mariano, Gandur Quiroga María Natalia, Pasik Leonardo
Departamento de Oncología Clínica, Instituto de Oncología ángel H. Roffo, Universidad de Buenos Aires, Argentina. E-mail:
Departamento de Oncología Clínica, Instituto de Oncología ángel H. Roffo, Universidad de Buenos Aires, Argentina.
Medicina (B Aires). 2019;79(1):67-70.
Teratomas are malign germ cell tumors composed of two or more tissue layers. When there is specific organ differentiation they are called mature teratoma. They rarely grow aggressively. We report the case of a 29 year-old man with a diagnosis of gonadal germ cell tumor whose evolution was unfavorable owing to transformation into a different phenotype corresponding to a rhabdomyosarcoma. This phenomenon occurs through differential growth of a single histological component of the original tumor or transformation of a somatic lineage that becomes dominant. Transformed tumors such as the one herein described differ from most germ cell neoplasms regarding behavior, prognosis, and susceptibility to established treatments.
畸胎瘤是由两个或更多组织层构成的恶性生殖细胞肿瘤。当存在特定器官分化时，它们被称为成熟畸胎瘤。它们很少侵袭性生长。我们报告一例29岁男性，诊断为性腺生殖细胞肿瘤，因其转变为对应横纹肌肉瘤的不同表型，病情进展不利。这种现象通过原始肿瘤单一组织学成分的差异性生长或占主导地位的体细胞谱系的转变而发生。本文所述的转化肿瘤在行为、预后和对既定治疗的敏感性方面与大多数生殖细胞肿瘤不同。
