Kotal P, Kotyk A
1st Department of Medicine, Charles University, Prague, Czechoslovakia.
Eur J Pharmacol. 1988 Oct 18;155(3):301-3. doi: 10.1016/0014-2999(88)90518-3.
Chloroquine, which is known to be concentrated in intracellular acid vesicles, stimulates the release of porphyrins from yeast. Experiments with normal baker's yeast Saccharomyces cerevisiae and the sec-1 mutant, with suppressed exocytosis, showed that the release of porphyrins was stimulated more in normal yeast than it was in the mutant. It is suggested that chloroquine stimulates the exocytosis of porphyrins.
已知集中在细胞内酸性囊泡中的氯喹会刺激酵母释放卟啉。对正常面包酵母酿酒酵母和分泌受抑制的sec-1突变体进行的实验表明，正常酵母中卟啉的释放比突变体中受到的刺激更大。这表明氯喹刺激了卟啉的胞吐作用。
