Taghizadeh Niloofar, Eslaminejad Alireza, Raoufy Mohammad Reza
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Respir Physiol Neurobiol. 2019 Apr;262:49-56. doi: 10.1016/j.resp.2019.01.011. Epub 2019 Jan 26.
Psychological stress can provoke airway constriction in asthmatic patients, which may be because of autonomic nervous system dysfunction in asthma. We investigated the effect of enhancing respiratory sinus arrhythmia using heart rate variability biofeedback (HRV-BF) on spirometry performance and HRV indices during stress induced by Stroop Color-Word interference test in asthmatic patients and healthy volunteers. Stress caused decrease in FEV1%, FVC%, and PEF% compared to baseline in asthmatic patients, but not in healthy subjects. A single short duration episode of HRV-BF not only had a protective effect on stress-induced airway constriction, but also significantly augmented the level of FEV1% and FVC% as compared with their own baseline. Also, there was a significant correlation between HRV changes and the augmentation of spirometry performance in asthmatic patients receiving HRV-BF. Our findings indicated that even a single short duration episode of HRV-BF can decrease susceptibility to stress-induced lung function impairment in patients with asthma, which may be through the modulation of respiratory sinus arrhythmia.
心理压力可诱发哮喘患者气道收缩，这可能是由于哮喘患者自主神经系统功能障碍所致。我们研究了在哮喘患者和健康志愿者中，通过心率变异性生物反馈（HRV-BF）增强呼吸性窦性心律不齐对在Stroop颜色-文字干扰测试诱导的应激期间肺功能测定表现和HRV指标的影响。与基线相比，应激导致哮喘患者的第一秒用力呼气容积百分比（FEV1%）、用力肺活量百分比（FVC%）和呼气峰值流速百分比（PEF%）下降，但健康受试者未出现这种情况。单次短时间的HRV-BF不仅对应激诱导的气道收缩具有保护作用，而且与自身基线相比，还显著提高了FEV1%和FVC%的水平。此外，在接受HRV-BF的哮喘患者中，HRV变化与肺功能测定表现的改善之间存在显著相关性。我们的研究结果表明，即使是单次短时间的HRV-BF也可以降低哮喘患者对应激诱导的肺功能损害的易感性，这可能是通过调节呼吸性窦性心律不齐实现的。
