“乳激素”是否是与运动相关的神经可塑性的关键因素？基于替代的乳酸神经生物学途径的假设。
Is the "lactormone" a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway.
机构信息
Post-graduate Program of Health Sciences, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil; Physical Education and Sport Department, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil; Post-Graduate Program of Medicine (Neurology/Neuroscience), Federal Fluminense University, Niterói, Rio de Janeiro, Brazil; Psychiatry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Laboratoire Techniques et Enjeux du Corps (TEC) | EA 3625, Université Paris Descartes, Sorbonne Paris Cité, France.
出版信息
Med Hypotheses. 2019 Feb;123:63-66. doi: 10.1016/j.mehy.2018.12.013. Epub 2018 Dec 24.
For many years lactate was seen as a metabolite from glucose metabolism. However, since the last century researchers have shown that this molecule has an important role on liver, muscle, and brain metabolism. Lactate traffics along whole body mediating many biological processes depending on specific situations. For example, glucose is the main substrate used during exercise but lactate released by striated skeletal muscle is used by own muscle as secondary fuel. On the other hand, neuronal firing in the brain is almost totally lactate-dependent. In addition, lactate has an important role on BDNF-mediated neuroplasticity. As this molecule has a pleiotropic role in the body, it was called as "lactormone" in 2009. Here we show basic concepts on peripheral and central metabolism and discuss neurobiological pathways of lactate, including an alternative hypothesis on lactate released during exercise.
多年来，乳酸一直被视为葡萄糖代谢的一种代谢产物。然而，自上个世纪以来，研究人员已经表明，这种分子在肝脏、肌肉和大脑代谢中具有重要作用。乳酸在全身范围内运输，根据特定情况调节许多生物过程。例如，葡萄糖是运动期间使用的主要底物，但横纹肌释放的乳酸被自身肌肉用作次要燃料。另一方面，大脑中的神经元放电几乎完全依赖于乳酸。此外，乳酸在 BDNF 介导的神经可塑性中具有重要作用。由于这种分子在体内具有多效性作用，因此它在 2009 年被称为“乳激素”。在这里，我们展示了外周和中枢代谢的基本概念，并讨论了乳酸的神经生物学途径，包括运动期间释放乳酸的替代假设。
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