gene: its function and dysregulation in cancer.

In this review, we summarise the function and structure of telomerase reverse transcriptase () in humans, including its regulation. The dysregulation of telomerase through promoter mutations across a range of cancers is discussed. The molecular mechanism activated by promoter mutations is outlined. Finally, the timing of promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.