醋丁洛尔和拉贝洛尔对健康志愿者外周血流动力学的比较作用。

Comparative effects of acebutolol and labetalol on peripheral hemodynamics in healthy volunteers.

Wurm M, Kantelip J P, Duchene-Marullaz P

Institut de Recherches Cardiovasculaires de Royat, Clermont-Ferrand, France.

Fundam Clin Pharmacol. 1988;2(5):405-11. doi: 10.1111/j.1472-8206.1988.tb01006.x.

Abstract

During a 28-day treatment period, 10 healthy volunteers in a cross-over, double-blind study received at random 200 mg of either acebutolol or labetalol twice a day. Each treatment period was followed by administration of a placebo over an equal length of time. 2. Only acebutolol reduced heart rate measured in the supine position significantly at rest, whereas acebutolol and labetalol reduced it significantly after exercise on the treadmill. 3. Only acebutolol lowered humeral pressure at rest but not after exercise. Neither drug produced a change in blood pressure in the ankle or in the first toe at rest or after exercise. 4. Blood flow measured by plethysmography was increased by labetalol in the calf by comparison with placebo and in the first toe by comparison with placebo and acebutolol. 5. Labetalol lowered peripheral resistance significantly in comparison with placebo in the calf and first toe. Acebutolol tended to lower the resistance insignificantly in the calf but to increase resistance in the first toe.

摘要

在为期28天的治疗期内，10名健康志愿者参与了一项交叉双盲研究，他们被随机分配，每天两次服用200毫克醋丁洛尔或拉贝洛尔。每个治疗期之后是一段相同时长的安慰剂服用期。
只有醋丁洛尔能显著降低静息时仰卧位测量的心率，而醋丁洛尔和拉贝洛尔在跑步机运动后能显著降低心率。
只有醋丁洛尔能降低静息时的肱动脉血压，但运动后不能。两种药物在静息或运动后均未引起踝部或大脚趾血压的变化。
通过体积描记法测量，与安慰剂相比，拉贝洛尔使小腿血流量增加，与安慰剂和醋丁洛尔相比，拉贝洛尔使大脚趾血流量增加。
与安慰剂相比，拉贝洛尔显著降低了小腿和大脚趾的外周阻力。醋丁洛尔倾向于使小腿阻力略有降低，但使大脚趾阻力增加。