Roelofse J A, Shipton E A, Joubert J J, Grotepass F W
Faculty of Dentistry, University of Stellenbosch, Cape Town, South Africa.
J Oral Maxillofac Surg. 1987 Oct;45(10):835-41. doi: 10.1016/0278-2391(87)90231-x.
Arterial blood pressure and pulse rate changes following tracheal intubation were studied in 80 patients undergoing oral surgical procedures who received an etomidate/suxamethonium anesthetic induction sequence. Three treatment groups and a control group were used. Intravenous labetalol (1 mg/kg), acebutolol (0.25 mg/kg), lidocaine (2 mg/kg), and saline (1 ml), injected prior to anesthesia, were compared with respect to their effect on the hemodynamic consequences of direct laryngoscopy followed by the passage of an endotracheal tube. A pre-induction dose of labetalol was found to be more effective than acebutolol and lidocaine in attenuating the pressor response to instrumentation and intubation. Labetalol should prove most useful for those patients at risk from the transient hypertension and tachycardia following instrumentation and intubation.
对80例接受依托咪酯/琥珀胆碱麻醉诱导顺序的口腔外科手术患者，研究了气管插管后的动脉血压和脉搏率变化。采用了三个治疗组和一个对照组。比较了麻醉前静脉注射拉贝洛尔（1mg/kg）、醋丁洛尔（0.25mg/kg）、利多卡因（2mg/kg）和生理盐水（1ml）对直接喉镜检查并插入气管导管后血流动力学影响的效果。发现诱导前剂量的拉贝洛尔在减轻对器械操作和插管的升压反应方面比醋丁洛尔和利多卡因更有效。拉贝洛尔对那些有因器械操作和插管后短暂高血压和心动过速风险的患者应该是最有用的。
