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Japan's approval of stem-cell treatment for spinal-cord injury concerns scientists.

作者信息

Cyranoski David

出版信息

Nature. 2019 Jan;565(7741):544-545. doi: 10.1038/d41586-019-00178-x.

DOI:10.1038/d41586-019-00178-x
PMID:30696963
Abstract
摘要

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Japan's approval of stem-cell treatment for spinal-cord injury concerns scientists.日本批准用干细胞疗法治疗脊髓损伤引发了科学家们的担忧。
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Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal-like cells in a spinal cord injury model.丹参酮 IIA 促进骨髓间充质干细胞向脊髓损伤模型中的神经元样细胞分化。
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Functional recovery in spinal cord injury using mesenchymal stem cells.使用间充质干细胞促进脊髓损伤后的功能恢复。
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Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy.间质干细胞治疗脊髓损伤:细胞疗法的现状、局限和未来。
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Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury.人脐带间充质干细胞与脊髓损伤的治疗
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Comparison of mesenchymal stem cells derived from fat, bone marrow, Wharton's jelly, and umbilical cord blood for treating spinal cord injuries in dogs.比较源自脂肪、骨髓、华通氏胶和脐带血的间充质干细胞对犬脊髓损伤的治疗效果。
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[Protective effect of transplantation of bone mesenchymal stem cells on demyelination in spinal cord injury].骨髓间充质干细胞移植对脊髓损伤脱髓鞘的保护作用
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Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury.慢性脊髓损伤患者自体骨髓间充质干细胞移植后的安全性及神经学评估
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Electroacupuncture promotes the differentiation of transplanted bone marrow mesenchymal stem cells overexpressing TrkC into neuron-like cells in transected spinal cord of rats.电针对过表达 TrkC 的骨髓间充质干细胞向大鼠横断脊髓中神经元样细胞的分化有促进作用。
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Stem cell therapies for spinal cord injury in humans: A review of recent clinical research.人类脊髓损伤的干细胞疗法:近期临床研究综述
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Stem Cell Therapies and Ageing: Unlocking the Potential of Regenerative Medicine.干细胞疗法与衰老:释放再生医学的潜力。
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Mesenchymal Stromal Cell-Based Products: Challenges and Clinical Therapeutic Options.基于间充质基质细胞的产品:挑战和临床治疗选择。
Int J Mol Sci. 2024 May 31;25(11):6063. doi: 10.3390/ijms25116063.
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CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis.过表达 CCR5 的间充质干细胞可预防实验性自身免疫性葡萄膜炎:单细胞转录组分析的见解。
J Neuroinflammation. 2024 May 27;21(1):136. doi: 10.1186/s12974-024-03134-3.
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Mesenchymal Stem Cell (MSC)-Based Drug Delivery into the Brain across the Blood-Brain Barrier.基于间充质干细胞的药物透过血脑屏障向脑内递送
Pharmaceutics. 2024 Feb 18;16(2):289. doi: 10.3390/pharmaceutics16020289.
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Mesenchymal Stem Cell-Induced Neuroprotection in Pediatric Neurological Diseases: Recent Update of Underlying Mechanisms and Clinical Utility.间充质干细胞诱导的儿科神经疾病神经保护:潜在机制和临床应用的最新进展。
Appl Biochem Biotechnol. 2024 Sep;196(9):5843-5858. doi: 10.1007/s12010-023-04752-y. Epub 2024 Jan 23.
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Cell and gene therapy approvals in Japan and the need for international harmonization.日本的细胞和基因疗法批准情况以及国际协调的必要性。
Nat Biotechnol. 2024 Jan;42(1):13-17. doi: 10.1038/s41587-023-02053-7.
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Mesenchymal Stem Cell Therapies Approved by Regulatory Agencies around the World.全球监管机构批准的间充质干细胞疗法
Pharmaceuticals (Basel). 2023 Sep 21;16(9):1334. doi: 10.3390/ph16091334.
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Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells.间充质干细胞对脊髓损伤的多模态修复
Neurospine. 2022 Sep;19(3):616-629. doi: 10.14245/ns.2244272.136. Epub 2022 Sep 30.
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Biomaterials reinforced MSCs transplantation for spinal cord injury repair.生物材料增强间充质干细胞移植用于脊髓损伤修复
Asian J Pharm Sci. 2022 Jan;17(1):4-19. doi: 10.1016/j.ajps.2021.03.003. Epub 2021 Apr 20.