Menzler Jacob, Neubauer Aljoscha Steffen, Haritoglou Christos, Jackson Timothy L
Institute for Health- and Pharmacoeconomics/Neubauer Consult, Munich, Germany,
Private practice, Munich, Germany.
Clin Ophthalmol. 2019 Jan 15;13:177-188. doi: 10.2147/OPTH.S188704. eCollection 2019.
Symptomatic vitreomacular adhesion (sVMA) comprises vitreomacular traction (VMT) and stage 1 and 2 full-thickness macular holes (MHs) associated with vitreomacular adhesion (VMA). We aimed to estimate the incidence and prevalence of sVMA in Germany.
A systematic literature review was conducted to identify the incidence and prevalence of sVMA based on international epidemiologic studies, weighted for study size and then averaged across eligible studies. A second systematic review aimed to estimate the proportion of vitrectomy undertaken for sVMA in Germany. This was combined with the reported number of vitrectomies in Germany in 2016 to estimate the number of patients undergoing vitrectomy for sVMA.
The prevalence of sVMA is 1,365 per 100,000 population, with an incidence of 6.96 per 100,000 per year. For Germany, this translates to 1,119,300 cases, with 5,700 new cases reported annually. Analyzing the national hospital statistics, ~2,300 patients undergo vitrectomy due to sVMA in Germany each year, of which about 1,700 patients have VMT.
Incidence figures, driven by patients presenting to clinic, are much lower than expected based on population-based studies, suggesting that many patients with sVMA exist outside of the clinic system.
有症状的玻璃体黄斑粘连（sVMA）包括玻璃体黄斑牵引（VMT）以及与玻璃体黄斑粘连（VMA）相关的1期和2期全层黄斑裂孔（MH）。我们旨在估算德国sVMA的发病率和患病率。
进行了一项系统的文献综述，以根据国际流行病学研究确定sVMA的发病率和患病率，并根据研究规模加权，然后在符合条件的研究中求平均值。第二项系统综述旨在估算德国因sVMA进行玻璃体切除术的比例。将其与2016年德国报告的玻璃体切除术数量相结合，以估算因sVMA接受玻璃体切除术的患者数量。
sVMA的患病率为每10万人中有1365例，年发病率为每10万人中有6.96例。对于德国而言，这相当于1119300例病例，每年报告5700例新病例。分析国家医院统计数据，德国每年约有2300例患者因sVMA接受玻璃体切除术，其中约1700例患者患有VMT。
由就诊患者推动的发病率数字远低于基于人群研究的预期，这表明许多患有sVMA的患者存在于临床系统之外。
