头孢洛林联合达托霉素治疗儿童难治性耐甲氧西林金黄色葡萄球菌菌血症
Ceftaroline Plus Daptomycin for Refractory Methicillin- Resistant Staphylococcus aureus Bacteremia in a Child.
作者信息
Hall Alan M, McTigue Sean M
出版信息
J Pediatr Pharmacol Ther. 2018 Nov-Dec;23(6):490-493. doi: 10.5863/1551-6776-23.6.490.
Abstract
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be difficult to treat, with growing adult literature supporting the combination of ceftaroline and daptomycin for these patients. Here, we report a pediatric patient with persistent MRSA bacteremia with associated cellulitis, fasciitis, myositis, and a deep venous thrombosis causing septic pulmonary emboli. After being unable to clear the bacteremia on vancomycin and then daptomycin monotherapy, the bacteremia cleared quickly with rapid clinical improvement after the addition of ceftaroline to daptomycin. In support of this case, we also review the adult literature supporting treatment with this combination of antibiotics.
摘要
持续性耐甲氧西林金黄色葡萄球菌（MRSA）菌血症可能难以治疗，越来越多的成人文献支持使用头孢洛林和达托霉素联合治疗这些患者。在此，我们报告一名患有持续性MRSA菌血症并伴有蜂窝织炎、筋膜炎、肌炎以及导致感染性肺栓塞的深静脉血栓形成的儿科患者。在万古霉素及随后的达托霉素单药治疗均无法清除菌血症后，在达托霉素中加入头孢洛林后，菌血症迅速清除，临床症状迅速改善。为支持该病例，我们还回顾了支持使用这种抗生素联合治疗的成人文献。
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本文引用的文献
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Pediatr Infect Dis J. 2018 Sep;37(9):893-900. doi: 10.1097/INF.0000000000001926.
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