González-González Marianela, Díaz-Zepeda Camilo, Eyzaguirre-Velásquez Johana, González-Arancibia Camila, Bravo Javier A, Julio-Pieper Marcela
Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Front Physiol. 2019 Jan 15;9:1962. doi: 10.3389/fphys.2018.01962. eCollection 2018.
A growing number of investigations report the association between gut permeability and intestinal or extra-intestinal disorders under the basis that translocation of gut luminal contents could affect tissue function, either directly or indirectly. Still, in many cases it is unknown whether disruption of the gut barrier is a causative agent or a consequence of these conditions. Adequate experimental models are therefore required to further understand the pathophysiology of health disorders associated to gut barrier disruption and to develop and test pharmacological treatments. Here, we review the current animal models that display enhanced intestinal permeability, and discuss (1) their suitability to address mechanistic questions, such as the association between gut barrier alterations and disease and (2) their validity to test potential treatments for pathologies that are characterized by enhanced intestinal permeability.
越来越多的研究报告了肠道通透性与肠道或肠道外疾病之间的关联，其依据是肠腔内容物的易位可能直接或间接影响组织功能。然而，在许多情况下，尚不清楚肠道屏障的破坏是这些疾病的致病因素还是结果。因此，需要适当的实验模型来进一步了解与肠道屏障破坏相关的健康障碍的病理生理学，并开发和测试药物治疗方法。在这里，我们综述了目前显示肠道通透性增强的动物模型，并讨论了（1）它们对于解决机制性问题（如肠道屏障改变与疾病之间的关联）的适用性，以及（2）它们对于测试以肠道通透性增强为特征的疾病的潜在治疗方法的有效性。
