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Commentary: Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.评论：单链端粒结合蛋白利用双变阻器调节结合亲和力和特异性以驱动功能。
Front Genet. 2019 Jan 15;9:742. doi: 10.3389/fgene.2018.00742. eCollection 2018.
2
Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.单链端粒结合蛋白采用双重变阻器来调节结合亲和力和特异性，从而驱动其功能。
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10315-10320. doi: 10.1073/pnas.1722147115. Epub 2018 Sep 24.
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Rice proteins that bind single-stranded G-rich telomere DNA.与富含鸟嘌呤的单链端粒DNA结合的水稻蛋白。
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Site-directed mutagenesis reveals the thermodynamic requirements for single-stranded DNA recognition by the telomere-binding protein Cdc13.定点诱变揭示了端粒结合蛋白Cdc13识别单链DNA的热力学要求。
Biochemistry. 2003 Apr 8;42(13):3751-8. doi: 10.1021/bi027047c.
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Identification of HMG-5 as a double-stranded telomeric DNA-binding protein in the nematode Caenorhabditis elegans.鉴定HMG-5为线虫秀丽隐杆线虫中的一种双链端粒DNA结合蛋白。
FEBS Lett. 2003 Nov 20;554(3):455-61. doi: 10.1016/s0014-5793(03)01191-8.
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Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences.粟酒裂殖酵母中的两种端粒盒蛋白Taz1p和Teb1p识别不同的端粒相关DNA序列。
Nucleic Acids Res. 1999 Dec 15;27(24):4687-94. doi: 10.1093/nar/27.24.4687.
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A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei.一类酵母细胞核中Rap1p定位所需的单链端粒DNA结合蛋白。
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5558-62. doi: 10.1073/pnas.92.12.5558.
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Characterization and developmental expression of single-stranded telomeric DNA-binding proteins from mung bean (Vigna radiata).绿豆（Vigna radiata）单链端粒DNA结合蛋白的表征及发育表达
Plant Mol Biol. 2000 Mar;42(4):547-57. doi: 10.1023/a:1006373917321.
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Delineation of the high-affinity single-stranded telomeric DNA-binding domain of Saccharomyces cerevisiae Cdc13.酿酒酵母Cdc13高亲和力单链端粒DNA结合结构域的描绘
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Est1 has the properties of a single-stranded telomere end-binding protein.Est1具有单链端粒末端结合蛋白的特性。
Genes Dev. 1996 Dec 15;10(24):3094-104. doi: 10.1101/gad.10.24.3094.

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Immune Diseases Associated with Aging: Molecular Mechanisms and Treatment Strategies.与衰老相关的免疫疾病：分子机制和治疗策略。
Int J Mol Sci. 2023 Oct 25;24(21):15584. doi: 10.3390/ijms242115584.
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Step-by-Step Evolution of Telomeres: Lessons from Yeasts.端粒的逐步进化：来自酵母菌的启示。
Genome Biol Evol. 2021 Feb 3;13(2). doi: 10.1093/gbe/evaa268.
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Co-evolution in the Jungle: From Leafcutter Ant Colonies to Chromosomal Ends.叶切蚁群体中的共进化：从叶切蚁群体到染色体末端
J Mol Evol. 2020 May;88(4):293-318. doi: 10.1007/s00239-020-09935-3. Epub 2020 Mar 10.

本文引用的文献

1
Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.单链端粒结合蛋白采用双重变阻器来调节结合亲和力和特异性，从而驱动其功能。
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10315-10320. doi: 10.1073/pnas.1722147115. Epub 2018 Sep 24.
2
Shelterin-Mediated Telomere Protection.端粒保护的庇护体机制。
Annu Rev Genet. 2018 Nov 23;52:223-247. doi: 10.1146/annurev-genet-032918-021921. Epub 2018 Sep 12.
3
Transposon control mechanisms in telomere biology.端粒生物学中转座子控制机制。
Curr Opin Genet Dev. 2018 Apr;49:56-62. doi: 10.1016/j.gde.2018.03.002. Epub 2018 Mar 20.
4
Double-stranded telomeric DNA binding proteins: Diversity matters.双链端粒 DNA 结合蛋白：多样性很重要。
Cell Cycle. 2017;16(17):1568-1577. doi: 10.1080/15384101.2017.1356511. Epub 2017 Jul 27.
5
Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins.裂殖酵母端粒的进化及其与端粒结合蛋白多样化的可能关系。
PLoS One. 2016 Apr 21;11(4):e0154225. doi: 10.1371/journal.pone.0154225. eCollection 2016.
6
Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites.酵母亚门酵母中的端粒DNA识别：单链DNA和双链DNA结合蛋白及其靶位点共同进化的潜在启示
Front Genet. 2015 May 1;6:162. doi: 10.3389/fgene.2015.00162. eCollection 2015.
7
Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.转录因子家族中DNA特异性的进化产生了一个新的基因调控模块。
Cell. 2014 Sep 25;159(1):58-68. doi: 10.1016/j.cell.2014.09.003.
8
Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution.低亲和力转录因子结合位点塑造形态发生素反应和增强子进化。
Philos Trans R Soc Lond B Biol Sci. 2013 Nov 11;368(1632):20130018. doi: 10.1098/rstb.2013.0018. Print 2013 Dec 19.
9
Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.Tay1 蛋白的两个 Myb 结构域的协同作用导致其与端粒具有高亲和力结合。
J Biol Chem. 2012 Sep 14;287(38):32206-15. doi: 10.1074/jbc.M112.385591. Epub 2012 Jul 18.
10
The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters.中等效率的酶：塑造酶参数的进化和物理化学趋势。
Biochemistry. 2011 May 31;50(21):4402-10. doi: 10.1021/bi2002289. Epub 2011 May 4.

Commentary: Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.

作者信息

Tomáška Ĺubomír, Nosek Jozef, Sepšiová Regina, Červenák Filip, Juríková Katarína, Procházková Katarína, Neboháčová Martina, Willcox Smaranda, Griffith Jack D

机构信息

Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.

Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.

出版信息

Front Genet. 2019 Jan 15;9:742. doi: 10.3389/fgene.2018.00742. eCollection 2018.

DOI:10.3389/fgene.2018.00742
PMID:30697232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6341069/
Abstract
摘要