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骨闪烁显像在双膦酸盐相关颌骨坏死早期诊断中的应用。病例报告及文献复习。

Use of bone scintigraphy in the early diagnosis of bisphosphonate related osteonecrosis of the jaw. Case report and review of the literature.

作者信息

Sánchez-López José-Darío, Cariati Paolo, Cambil-Martin Jacobo, Villegas-Calvo Mercedes, Moreno-Martin María-Luisa

机构信息

Department of Oral an Maxillofacial Surgery. Universitary Hospital "Virgen de las Nieves". Granada (Spain).

Department of Healthcare . University of Granada (Spain).

出版信息

J Clin Exp Dent. 2018 Dec 1;10(12):e1235-e1237. doi: 10.4317/jced.55248. eCollection 2018 Dec.

DOI:10.4317/jced.55248
PMID:30697384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6343969/
Abstract

The main aim of the present report is to show the potential utility of bone scintigraphy for the diagnosis of jaw osteonecrosis. We report the history of a 62-year-old woman underwent breast cancer surgery in 2010. Moreover, patient received postoperative radiotherapy and chemotherapy. Intravenous bisphosphonates were also added to the treatment strategy to reduce the risk of bone metastasis. However, a hypermetabolic focus on left hemimandible was evidenced with a bone scintigraphy during follow up. After a careful study, the diagnosis of Bisphosphonate Related Ostneonecrosis of the Jaw (BRONJ) was carried out. This case highlights that bone scintigraphy may be extremely helpful for the early detection of BRONJ in high risk patient. Bone scintigraphy, mandibular osteonecrosis, bisphosphonates.

摘要

本报告的主要目的是展示骨闪烁显像在诊断颌骨坏死方面的潜在效用。我们报告一名62岁女性的病史，她于2010年接受了乳腺癌手术。此外，患者接受了术后放疗和化疗。静脉注射双膦酸盐也被纳入治疗策略以降低骨转移风险。然而，在随访期间的骨闪烁显像显示左半下颌骨有一个高代谢灶。经过仔细研究，诊断为双膦酸盐相关颌骨骨坏死（BRONJ）。该病例突出表明，骨闪烁显像对于高危患者早期发现BRONJ可能极其有用。骨闪烁显像、下颌骨坏死、双膦酸盐。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/6bd69c7d0fe5/jced-10-e1235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/51ae430d98ed/jced-10-e1235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/ec91a171caf0/jced-10-e1235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/6bd69c7d0fe5/jced-10-e1235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/51ae430d98ed/jced-10-e1235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/ec91a171caf0/jced-10-e1235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5f/6343969/6bd69c7d0fe5/jced-10-e1235-g003.jpg

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本文引用的文献

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Surgical evaluation of panoramic radiography and cone beam computed tomography for therapy planning of bisphosphonate-related osteonecrosis of the jaws.
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