Department of Odontostomatology, Dental School;
Ther Clin Risk Manag. 2009 Feb;5(1):217-27. doi: 10.2147/tcrm.s1697. Epub 2009 Mar 26.
Since osteonecrosis of the jaw was related to biphosphonate administration by Marx, studies showing clinical symptoms, drug and surgical therapies overwhelmed the literature. Furthermore, the literature demonstrated the correlation between chronic biphosphonate adsumption and osteonecrosis of the jaw onset. Nitrogen-containing biphosphonates are widely used for the management of metastatic cancer, for prevention and treatment of osteoporosis, for the treatment of Paget's disease, and for the management of acute hypercalcemia. According to our experience, the treatment of BRON-J's lesions is difficult and prolonged. For this reason, in order to avoid these complications it is mandatory to perform a risk staging in patients who must undergo biphosphonate administration. When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved.
由于颌骨坏死与双膦酸盐的应用有关，因此文献中充斥着大量显示临床症状、药物和手术治疗的研究。此外，文献还表明了慢性双膦酸盐摄入与颌骨坏死发生之间的相关性。含氮双膦酸盐广泛用于治疗转移性癌症、预防和治疗骨质疏松症、治疗 Pagets 病以及治疗急性高钙血症。根据我们的经验，BRON-J 病变的治疗困难且漫长。因此，为了避免这些并发症，必须对将要接受双膦酸盐治疗的患者进行风险分期。当使用抗生素和局部防腐剂进行药物治疗无法控制 BRON-J 并发症的发展时，临床医生应进行根治性手术治疗，例如切除受累的骨头。
