Winter P M, Amon M, Höcker P
Institut für Blutgruppenserologie der Universität Wien, National Blood Group Reference Laboratory (WHO).
Infusionstherapie. 1988 Dec;15(6):251-3. doi: 10.1159/000222301.
A febrile transfusion reaction caused by strong isoagglutinins in the patients serum is reported. The reaction resulted from a transfusion of group A platelets in a group 0 patient; the recipients' serum contained high titered isohemagglutinin (Anti-A 1:8192) capable of lysing bloodgroup A1 red cells up to a titer of 1:8. Moreover, the serum showed a strong positive thrombocytotoxic reaction with the platelets of the donor and some other group A individuals, but remained negative with group 0, and turned to negative reaction with group A samples after neutralization with bloodgroup substance. We conclude that pretransfusion testing of group 0 donors and recipients for isohemolysins combined with platelet crossmatching may prevent febrile reactions.
报道了一例由患者血清中强同种凝集素引起的发热性输血反应。该反应是由于一名O型患者输注了A型血小板所致；受者血清中含有高滴度的同种血凝素（抗A 1:8192），能够裂解效价高达1:8的A1血型红细胞。此外，该血清与供者及其他一些A型个体的血小板呈现强烈的血小板毒性阳性反应，但与O型血小板反应呈阴性，在用血型物质中和后，与A型样本的反应转为阴性。我们得出结论，对O型供者和受者进行同种溶血素的输血前检测并结合血小板交叉配型可预防发热反应。
