用于评估肉瘤的临床前PET示踪剂：了解肿瘤生物学
Preclinical PET tracers for the evaluation of sarcomas: understanding tumor biology.
作者信息
Sigal Ian R, Sebro Ronnie
机构信息
Department of Radiology, University of Pennsylvania 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Orthopedic Surgery, University of Pennsylvania 3400 Spruce Street, Philadelphia, PA 19104, USA.
出版信息
Am J Nucl Med Mol Imaging. 2018 Dec 20;8(6):428-440. eCollection 2018.
Abstract
Sarcomas are rare tumors of mesenchymal origin. Sarcomas display significant histological heterogeneity, resulting in significant imaging heterogeneity. F-FDG PET has is increasingly used for the evaluation, staging and surveillance of patients with sarcomas. F-FDG PET maximum SUV has been shown to be correlated with sarcoma grade and overall survival. This has led to interest in alternative PET tracers to assess the biological characteristics of tumors and guide treatment decisions. Here we investigate novel PET/CT tracers used for the evaluation of sarcomas over the past 20 years and summarize what we have learned about sarcoma tumor biology from these studies.
摘要
肉瘤是间叶组织来源的罕见肿瘤。肉瘤具有显著的组织学异质性，导致显著的影像学异质性。F-FDG PET越来越多地用于肉瘤患者的评估、分期和监测。F-FDG PET最大标准化摄取值已被证明与肉瘤分级和总生存期相关。这引发了人们对替代PET示踪剂的兴趣，以评估肿瘤的生物学特征并指导治疗决策。在此，我们研究了过去20年中用于评估肉瘤的新型PET/CT示踪剂，并总结了我们从这些研究中学到的关于肉瘤肿瘤生物学的知识。
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