Mao Yafei
Marine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan.
PeerJ. 2019 Jan 23;7:e6303. doi: 10.7717/peerj.6303. eCollection 2019.
Understanding whole genome duplication (WGD), or polyploidy, is fundamental to investigating the origin and diversification of organisms in evolutionary biology. The wealth of genomic data generated by next generation sequencing (NGS) has resulted in an urgent need for handy and accurate tools to detect WGD. Here, I present a useful and user-friendly pipeline called GenoDup for inferring WGD using the dS-based method. I have successfully applied GenoDup to identify WGD in empirical data from both plants and animals. The GenoDup Pipeline provides a reliable and useful tool to infer WGD from NGS data.
了解全基因组复制（WGD），即多倍体现象，对于在进化生物学中研究生物的起源和多样性至关重要。新一代测序（NGS）产生的大量基因组数据使得迫切需要便捷且准确的工具来检测WGD。在此，我介绍一种名为GenoDup的实用且用户友好的流程，用于使用基于dS的方法推断WGD。我已成功将GenoDup应用于识别来自植物和动物的经验数据中的WGD。GenoDup流程为从NGS数据推断WGD提供了一个可靠且有用的工具。
