T 型通道药物研发的十字路口。
T-Type Channel Druggability at a Crossroads.
机构信息
Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Prague 166 10 , Czech Republic.
Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine , University of Calgary , Calgary T2N4N1 , Canada.
出版信息
ACS Chem Neurosci. 2019 Mar 20;10(3):1124-1126. doi: 10.1021/acschemneuro.9b00031. Epub 2019 Jan 30.
Low-voltage activated T-type calcium channels mediate essential functions in the nervous system, and alteration of channel activity is causally linked to a number of neurological conditions. Therefore, T-type channels hold great promise as pharmacological targets for new medicines. In this Viewpoint, we discuss the potential of T-type channels as druggable targets and reevaluate the strategies available for developing therapeutically efficient and specific modulators of this channel.
低电压激活的 T 型钙通道在神经系统中介导基本功能，通道活性的改变与许多神经疾病有因果关系。因此，T 型通道作为新药的药理学靶点具有很大的潜力。在本观点中，我们讨论了 T 型通道作为可成药靶点的潜力，并重新评估了开发这种通道治疗有效和特异性调节剂的现有策略。
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