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自体骨髓移植后成功提取精子细胞:一例报告。

Successful extraction of sperm cells after autologous bone marrow transplant: a case report.

作者信息

Jacobsen Frederik M, Fode Mikkel, Sønksen Jens, Ohl Dana A, Jensen Christian Fuglesang S

机构信息

a Department of Urology , Herlev and Gentofte Hospital, University of Copenhagen , Herlev , Denmark.

b Department of Urology , University of Michigan , Ann Arbor , MI , USA.

出版信息

Scand J Urol. 2019 Apr-Jun;53(2-3):174-175. doi: 10.1080/21681805.2019.1570329. Epub 2019 Jan 30.

Abstract

We present a case where microdissection testicular sperm extraction (m.T.E.S.E.) was used in a 36-year-old man after non-Hodgkin T-cell lymphoma treated with 2.5 years of chemotherapy, radiation therapy and autologous bone marrow transplantation (B.M.T.). During m.T.E.S.E. two areas of testis tissue with dilated seminiferous tubules were found both containing several sperm cells. These were cryopreserved and subsequently used for intracytoplasmic sperm injection, resulting in a pregnancy. Although the prognosis for sperm retrieval appears to be poor in most men who have undergone B.M.T., our case demonstrates that this is not an absolute conclusion.

摘要

我们报告了一例36岁男性的病例,该男性在接受了2.5年的化疗、放疗和自体骨髓移植(B.M.T.)治疗非霍奇金T细胞淋巴瘤后,采用了显微切割睾丸取精术(m.T.E.S.E.)。在m.T.E.S.E.过程中,发现睾丸组织有两个区域的生精小管扩张,均含有多个精子细胞。这些精子细胞被冷冻保存,随后用于卵胞浆内单精子注射,结果成功受孕。尽管在大多数接受过B.M.T.的男性中,精子获取的预后似乎很差,但我们的病例表明这并非绝对定论。

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