Bourdon Jessica L, Savage Jeanne E, Verhulst Brad, Carney Dever M, Brotman Melissa A, Pine Daniel S, Leibenluft Ellen, Roberson-Nay Roxann, Hettema John M
Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Emotion and Development Branch,National Institute of Mental Health, National Institutes of Health,Department of Health and Human Services, Bethesda, MD,USA.
Twin Res Hum Genet. 2019 Feb;22(1):48-55. doi: 10.1017/thg.2018.73. Epub 2019 Jan 30.
This study uses novel approaches to examine genetic and environmental influences shared between childhood behavioral inhibition (BI) and symptoms of preadolescent anxiety disorders. Three hundred and fifty-two twin pairs aged 9-13 and their mothers completed questionnaires about BI and anxiety symptoms. Biometrical twin modeling, including a direction-of-causation design, investigated genetic and environmental risk factors shared between BI and social, generalized, panic and separation anxiety. Social anxiety shared the greatest proportion of genetic (20%) and environmental (16%) variance with BI with tentative evidence for causality. Etiological factors underlying BI explained little of the risk associated with the other anxiety domains. Findings further clarify etiologic pathways between BI and anxiety disorder domains in children.
本研究采用新颖的方法来检验儿童期行为抑制（BI）与青春期前焦虑症症状之间共享的遗传和环境影响。352对年龄在9至13岁的双胞胎及其母亲完成了关于BI和焦虑症状的问卷调查。双生子生物统计学模型，包括因果关系设计，研究了BI与社交焦虑、广泛性焦虑、惊恐障碍和分离焦虑之间共享的遗传和环境风险因素。社交焦虑与BI共享了最大比例的遗传方差（20%）和环境方差（16%），并有初步的因果关系证据。BI背后的病因因素对与其他焦虑领域相关的风险解释甚少。研究结果进一步阐明了儿童BI与焦虑症领域之间的病因途径。
