评“帕罗伐他汀可减少青少年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性”。
Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.
机构信息
Translational Research Program in Pediatric Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, United States.
出版信息
Elife. 2019 Jan 30;8:e43173. doi: 10.7554/eLife.43173.
Abstract
We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018).
摘要
我们写信是为了对 Lees-Shepard 等人（2018 年）最近发表的研究表示关注。
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引用本文的文献
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Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.对“帕罗伐他汀可减少青少年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性”一文的评论作出回应。
Elife. 2019 Jan 30;8:e43928. doi: 10.7554/eLife.43928.
本文引用的文献
1
Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity.帕拉罗伐醇可减少幼年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性。
Elife. 2018 Sep 18;7:e40814. doi: 10.7554/eLife.40814.
2
Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.帕罗维罗汀可抑制携带人类ACVR1（R206H）突变的进行性骨化性纤维发育不良（FOP）小鼠的异位骨化，并维持肢体活动能力和生长。
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3
Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.核维甲酸受体-γ 激动剂对异位骨化的强效抑制作用。
Nat Med. 2011 Apr;17(4):454-60. doi: 10.1038/nm.2334. Epub 2011 Apr 3.
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Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema.帕罗维罗汀，一种用于治疗肺气肿的新型维甲酸受体γ激动剂。
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