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Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.评“帕罗伐他汀可减少青少年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性”。
Elife. 2019 Jan 30;8:e43173. doi: 10.7554/eLife.43173.
2
Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.对“帕罗伐他汀可减少青少年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性”一文的评论作出回应。
Elife. 2019 Jan 30;8:e43928. doi: 10.7554/eLife.43928.
3
Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity.帕拉罗伐醇可减少幼年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性。
Elife. 2018 Sep 18;7:e40814. doi: 10.7554/eLife.40814.
4
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J Bone Miner Res. 2022 Oct;37(10):1891-1902. doi: 10.1002/jbmr.4655. Epub 2022 Aug 17.
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Palovarotene: First Approval.帕罗维罗替治疗法：首次批准。
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Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent.一种视黄酸激动剂与抗炎剂联合治疗异位骨化的有效性及作用方式
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Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat-related heterotopic ossification.帕罗维罗汀在与战斗相关的异位骨化大鼠模型中抑制结缔组织祖细胞增殖。
J Orthop Res. 2018 Apr;36(4):1135-1144. doi: 10.1002/jor.23747. Epub 2017 Nov 16.
10
Role of osteoclasts in heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice.破骨细胞在由进行性骨化性纤维发育不良相关的激活素样激酶2突变增强的小鼠异位骨化中的作用。
J Bone Miner Metab. 2016 Sep;34(5):517-25. doi: 10.1007/s00774-015-0701-3. Epub 2015 Jul 24.

引用本文的文献

1
Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.对“帕罗伐他汀可减少青少年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性”一文的评论作出回应。
Elife. 2019 Jan 30;8:e43928. doi: 10.7554/eLife.43928.

本文引用的文献

1
Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity.帕拉罗伐醇可减少幼年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性。
Elife. 2018 Sep 18;7:e40814. doi: 10.7554/eLife.40814.
2
Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.帕罗维罗汀可抑制携带人类ACVR1（R206H）突变的进行性骨化性纤维发育不良（FOP）小鼠的异位骨化，并维持肢体活动能力和生长。
J Bone Miner Res. 2016 Sep;31(9):1666-75. doi: 10.1002/jbmr.2820. Epub 2016 Mar 12.
3
Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.核维甲酸受体-γ 激动剂对异位骨化的强效抑制作用。
Nat Med. 2011 Apr;17(4):454-60. doi: 10.1038/nm.2334. Epub 2011 Apr 3.
4
Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema.帕罗维罗汀，一种用于治疗肺气肿的新型维甲酸受体γ激动剂。
Curr Opin Investig Drugs. 2009 Nov;10(11):1243-50.
5
Hypervitaminosis A in young ducks; the epiphyseal cartilages.幼鸭维生素A过多症；骨骺软骨
AMA Arch Pathol. 1953 Jan;55(1):47-54.
6
Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms.血小板衍生生长因子α受体信号传导机制的进化分歧
Mol Cell Biol. 2003 Jun;23(11):4013-25. doi: 10.1128/MCB.23.11.4013-4025.2003.
7
Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes.培养的人表皮角质形成细胞对全反式维甲酸的代谢
J Lipid Res. 1997 Jul;38(7):1374-83.
8
An analysis of retinoic acid-induced gene expression and metabolism in AB1 embryonic stem cells.视黄酸诱导的AB1胚胎干细胞基因表达与代谢分析。
J Biol Chem. 1996 Jun 21;271(25):14971-80. doi: 10.1074/jbc.271.25.14971.
9
Plasma delivery of retinoic acid to tissues in the rat.视黄酸在大鼠体内向组织的血浆递送。
J Biol Chem. 1995 Jul 28;270(30):17850-7. doi: 10.1074/jbc.270.30.17850.
10
Metabolism of all-trans-retinoic acid and all-trans-retinyl acetate. Demonstration of common physiological metabolites in rat small intestinal mucosa and circulation.全反式视黄酸和全反式醋酸视黄酯的代谢。大鼠小肠黏膜和循环中常见生理代谢产物的证明。
J Biol Chem. 1985 Sep 5;260(19):10590-6.

评“帕罗伐他汀可减少青少年 FOP 小鼠的异位骨化，但表现出明显的骨骼毒性”。

Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.

机构信息

Translational Research Program in Pediatric Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, United States.

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, United States.

出版信息

Elife. 2019 Jan 30;8:e43173. doi: 10.7554/eLife.43173.

DOI:10.7554/eLife.43173
PMID:30698141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6353590/
Abstract

We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018).

摘要

我们写信是为了对 Lees-Shepard 等人（2018 年）最近发表的研究表示关注。