Veloso Ronara Camila de Souza Groia, Figueredo Tácita Pires de, Barroso Soraya Coelho Costa, Nascimento Mariana Martins Gonzaga do, Reis Adriano Max Moreira
Residência Integrada Multiprofissional em Saúde, Hospital das Clínicas, Universidade Federal de Minas Gerais. Alameda Álvaro Celso 117, Santa Efigênia. 30130-100 Belo Horizonte MG Brasil.
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, UFMG. Belo Horizonte MG Brasil.
Cien Saude Colet. 2019 Jan;24(1):17-26. doi: 10.1590/1413-81232018241.32602016.
This study aims to determine the frequency of potential drug-drug interactions (PDI) in hospitalized elderly and associated factors. This is a cross-sectional study in a teaching hospital. The dependent variable was the occurrence of potential drug interactions identified using DrugReax software. Patients with adverse drug reactions (ADR) related to clinical manifestations of PDIs were also identified. Multivariate logistic regressions was performed to analyze the association between the occurrence of PDIs and independent variables. In total, 237 older adults were included in the study. The prevalence of PDIs and interaction-related ADRs was 87.8% and 6.8%, respectively. The multivariate analysis showed a positive association between the detection of PDIs (OR 8.6; 95% CI, 2.5-30.0), and hospitalization due to a diagnosed circulatory system disease and number of medications > 14 (OR 9.8; 95% CI, 2.8-34.3%). The study showed a high prevalence of PDIs in the drug treatment of the elderly, but a lower prevalence of ADRs, as well as a positive association between PDIs and hospitalization due to a diagnosed circulatory system disease and number of medications > 14. The identification of factors associated with PDIs guides prevention measures for people that are more exposed to adverse events.
本研究旨在确定住院老年人中潜在药物相互作用（PDI）的发生频率及相关因素。这是一项在教学医院开展的横断面研究。因变量是使用DrugReax软件识别出的潜在药物相互作用的发生情况。还识别出了与PDI临床表现相关的药物不良反应（ADR）患者。进行多因素逻辑回归分析以探讨PDI发生情况与自变量之间的关联。本研究共纳入237名老年人。PDI和与相互作用相关的ADR的患病率分别为87.8%和6.8%。多因素分析显示，检测到PDI（比值比8.6；95%置信区间，2.5 - 30.0）、因确诊循环系统疾病住院以及用药数量>14（比值比9.8；95%置信区间，2.8 - 34.3%）之间存在正相关。该研究表明，老年人药物治疗中PDI的患病率较高，但ADR的患病率较低，并且PDI与因确诊循环系统疾病住院以及用药数量>14之间存在正相关。识别与PDI相关的因素可为更易发生不良事件的人群指导预防措施。
