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乳腺癌生存率及预测因素:一项来自巴西亚马孙地区西部的基于医院的研究。

Survival rates of breast cancer and predictive factors: a hospital-based study from western Amazon area in Brazil.

作者信息

Fujimoto Ruth Helena Pimenta, Koifman Rosalina Jorge, Silva Ilce Ferreira da

机构信息

Programa de Pós-Graduação em Saúde Pública, Universidade Federal do Acre. Rodovia BR 364 Km 04, Distrito Industrial. 69920-900 Rio Branco AC Brasil.

Escola Nacional de Saúde Pública Sérgio Arouca, Fiocruz. Rio de Janeiro RJ Brasil.

出版信息

Cien Saude Colet. 2019 Jan;24(1):261-273. doi: 10.1590/1413-81232018241.35422016.

Abstract

Breast cancer survival in Latin America countries is below Central European countries. Hospital-based breast cancer survival studies in western Amazon, Brazil, are lacking. This article aims to estimate hospital-based breast cancer survival in Rio Branco, Acre, and predictor factors. Hospital-based cohort study of all women diagnosed with breast cancer (2007-2012) was proceeded. Information were obtained from medical reports, and follow-up was until 2013. One-, 2- and 5- years breast cancer specific-survival were estimated by Kaplan-Meier method. Crude and adjusted Harzards Ratios (HR) were estimated by proportional Cox regression model. One-, 2-, and 5-year overall breast cancer survival were 95.5%, 83.7%, and 87.3% respectively. Surgery combined to radiotherapy significantly affected 1-, 2-, and 5-year survival (99%, 94%, and 90.6%, respectively) as compared to other treatments (77%,57.1%, and 37.5%, respectively). Comparing to surgery combined to radiotherapy treatment, surgery alone increased the risk of death, independently of age and stage (HR = 7.23;95%CI:2.29-22.83). In Rio Branco, Acre, 5-year breast cancer survival is similar to more developed areas in Brazil. Surgery combined to radiotherapy was independently associated to a lower risk of death as compared to surgery alone and other treatment.

摘要

拉丁美洲国家的乳腺癌生存率低于中欧国家。巴西亚马逊西部缺乏基于医院的乳腺癌生存研究。本文旨在评估阿克里州里奥布兰科市基于医院的乳腺癌生存率及预测因素。对所有2007年至2012年诊断为乳腺癌的女性进行了基于医院的队列研究。从医疗报告中获取信息,随访至2013年。采用Kaplan-Meier法估计1年、2年和5年乳腺癌特异性生存率。通过比例Cox回归模型估计粗风险比和调整后风险比(HR)。1年、2年和5年乳腺癌总体生存率分别为95.5%、83.7%和87.3%。与其他治疗方法(分别为77%、57.1%和37.5%)相比,手术联合放疗显著影响1年、2年和5年生存率(分别为99%、94%和90.6%)。与手术联合放疗相比,单纯手术增加了死亡风险,与年龄和分期无关(HR = 7.23;95%CI:2.29 - 22.83)。在阿克里州里奥布兰科市,5年乳腺癌生存率与巴西更发达地区相似。与单纯手术和其他治疗方法相比,手术联合放疗与较低的死亡风险独立相关。

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