National Institute of Health (NIHR) Bristol Biomedical Research Centre, Nutrition Theme, University of Bristol, Bristol, United Kingdom.
Department of Population Health Sciences, University of Bristol Medical School, Bristol, United Kingdom.
Head Neck. 2019 Jul;41(7):2074-2084. doi: 10.1002/hed.25660. Epub 2019 Jan 30.
The association between diet and head and neck cancer (HNC) survival is unclear.
Cox proportional hazard models measured the association between fruit, vegetable, and deep-fried food intake and HNC overall survival adjusting for clinical, social and lifestyle variables including smoking, alcohol, and HPV status.
Fruit and vegetable intake and improved survival were associated in minimally adjusted analyses. Following adjustment for smoking and alcohol consumption (fully adjusted analyses), the association with survival disappeared for fruit (HR 0.91, 95% CI 0.67, 1.23; P for trend = .55) and attenuated for vegetables (HR 0.79, 95% CI 0.61, 1.03; P for trend = .04). We observed no association between survival and deep-fried food intake in minimally adjusted or fully adjusted analyses (HR 0.88 95% CI 0.72, 1.07; P for trend = .13).
Vegetable intake and HNC survival are modestly associated. There is some confounding by tobacco and alcohol consumption.
饮食与头颈部癌症（HNC）生存之间的关联尚不清楚。
Cox 比例风险模型通过调整临床、社会和生活方式变量（包括吸烟、饮酒和 HPV 状态），测量了水果、蔬菜和油炸食品摄入与 HNC 总生存之间的关联。
在最小调整分析中，水果和蔬菜的摄入与生存改善相关。在调整吸烟和饮酒（完全调整分析）后，水果与生存的关联消失（HR 0.91，95%CI 0.67，1.23；趋势 P 值=0.55），蔬菜的关联减弱（HR 0.79，95%CI 0.61，1.03；趋势 P 值=0.04）。我们在最小调整和完全调整分析中均未观察到生存与油炸食品摄入之间的关联（HR 0.88，95%CI 0.72，1.07；趋势 P 值=0.13）。
蔬菜摄入与 HNC 生存有适度的关联。吸烟和饮酒的消费存在一定的混杂因素。
