Institute for Advanced Studies , Taizhou University , 1139 Shifu Avenue , Taizhou 318000 , China.
Department of Chemistry , Fudan University , 2005 Songhu Road , Shanghai 200438 , China.
Org Lett. 2019 Feb 15;21(4):1156-1160. doi: 10.1021/acs.orglett.9b00100. Epub 2019 Jan 30.
A radical relay strategy for the generation of 3-(methylsulfonyl)benzo[ b]thiophenes through a reaction of methyl(2-alkynylphenyl)sulfanes with sodium metabisulfite in the presence of a photocatalyst under visible light irradiation is developed. This photoinduced sulfonylation proceeds efficiently under mild conditions by using a catalytic amount of sodium methylsulfinate as an initiator. During the reaction process, the methyl radical generated in situ is the key intermediate, which undergoes a radical relay with the combination of sulfur dioxide to afford methylsulfonyl-containing compounds.
开发了一种通过在可见光照条件下使用光催化剂，使甲基（2-炔基苯基）硫烷与亚硫酸氢钠反应生成 3-（甲基磺酰基）苯并[b]噻吩的自由基接力策略。该光诱导磺化反应在温和条件下，使用催化量的亚甲基磺酸钠作为引发剂，能有效地进行。在反应过程中，原位生成的甲基自由基是关键中间体，它与二氧化硫结合进行自由基接力，生成含甲基磺酰基的化合物。
