Zhu Jia-Nan, Wang Wen-Kang, Zhu Yuan, Hu Yin-Qiu, Zhao Sheng-Yin
College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai 201620 , People's Republic of China.
Org Lett. 2019 Aug 16;21(16):6270-6274. doi: 10.1021/acs.orglett.9b02153. Epub 2019 Jul 26.
A reductive radical relay strategy for the construction of fused benzo[]isoindole-1,3,5-trione through a reaction of α-bromo ketones with maleimides in the presence of Ir(ppy) under visible-light irradiation is described. The protocol employs very mild reaction conditions and offers satisfactory yields. Moreover, the reaction proceeds through a cascade C(sp)-Br/C(sp)-H functionalization, double C-C bond formation, and oxidative aromatization sequence.
描述了一种还原自由基接力策略，用于在可见光照射下，通过α-溴代酮与马来酰亚胺在Ir(ppy)存在下反应构建稠合苯并[ ]异吲哚-1,3,5-三酮。该方法采用非常温和的反应条件，并提供令人满意的产率。此外，反应通过级联C(sp)-Br/C(sp)-H官能团化、双C-C键形成和氧化芳构化序列进行。
